anti-IL12RB1 (IL12RB1) Antikörper

Cow (Bovine) Interleukin 12 Receptor beta 1 (IL12RB1) Interaktionspartner

1. Four SNPs in IFNGR2 (zeige IFNGR2 Antikörper), IL12RB1, IL12RB2 (zeige IL12RB2 Antikörper), and IL23R (zeige IL23R Antikörper) were found to be associated with the MAP infection status of the resource population.

Human Interleukin 12 Receptor beta 1 (IL12RB1) Interaktionspartner

1. A novel IL12RB1 N-terminal signal peptide stop-gain loss-of-function homozygous genotype connects three unrelated Brazilian kindreds with IL-12Rbeta1 deficiency with varying severity and early-onset age mainly regarding susceptibility to Mycobacteria, Histoplasma, and Salmonella infections through the paradoxical diminished cell-surface expression of an impaired IL-12Rbeta1 polypeptide.

2. Th17 cells expressed consistent high levels of the IL-12Rbeta1 subunit, which appeared a better predictor of responsiveness to IL-23 (zeige IL23A Antikörper) than the expression of the IL-23R (zeige IL23R Antikörper) subunit.

3. Polymorphisms of IFNG (zeige IFNG Antikörper), IL12B (zeige IL12B Antikörper) and IL12RB1 genes in paracoccidioidomycosis Brazilian patients do not affect the susceptibility or resistance to the disease.

4. The results of this case-control study suggest that IL-12A (zeige IL12A Antikörper), IL-12B (zeige IL12B Antikörper), IL12RB1, IL12RB2 (zeige IL12RB2 Antikörper) and IL23R (zeige IL23R Antikörper) make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations

5. Truncated IL12rbeta1/Fc is a novel fusion protein for specific binding multiple forms of p40 subunit to exert potent anti-inflammatory effects.

6. the introduction of RNA-DNA differences into an individual's IL12RB1 mRNA repertoire is a novel determinant of IL12 (zeige IL12A Antikörper)/23 sensitivity.

7. we describe cosegregation of a heterozygous germline defect in IL12RB1 and gastric cancer development in a family with IL-12Rbeta1 deficiency

8. individual variability in IL12RB1 function is introduced at the epigenetic, genomic polymorphism, and mRNA splicing levels [review]

9. Early coupled up-regulation of IL12RB1 in CD8 (zeige CD8A Antikörper)+ central memory and effector T cells result in better clinical outcomes in liver transplant recipients.

10. Genetic variations of IL-12B (zeige IL12B Antikörper), IL-12Rbeta1, IL-12Rbeta2 in Behcet's disease and VKH syndrome.

Mouse (Murine) Interleukin 12 Receptor beta 1 (IL12RB1) Interaktionspartner

1. the data support a model wherein IL12Rbeta1DeltaTM is a secreted product of il12rb1 that promotes resistance to M. tuberculosis infection by potentiating T(H) cells response to IL-12 (zeige IL12A Antikörper).

2. Although they share a common subunit, IL-23 (zeige IL23A Antikörper) and IL-12 (zeige IL12A Antikörper) receptors are not expressed on the same cell populations.

3. IL12RB1 is essential for human resistance to Mycobacterium tuberculosis infection

4. IL-12p40 is induced rapidly in response to Francisella tularensis LVS and is required for DC migration through an IL-12Rbeta1-IL-12(p40 (zeige IL12B Antikörper))2 dependent mechanism.

5. IL-12Rbeta1DeltaTM represents a novel regulator of IL12Rbeta1-dependent dendritic cell function and of the immune response to Mycobacterium tuberculosis.

6. IL-12R beta 1 deficiency results in decreased viral replication and inflammation following coxsackievirus B3-induced myocarditis, decreasing IL-1 beta (zeige IL1B Antikörper) and IL-18 (zeige IL18 Antikörper) in the heart.

7. The binding domain in the IL-12 receptor beta 1 cytoplasmic region has been mapped to sphingosine kinase 2 (zeige SPHK2 Antikörper).

8. Expression of the IL-12 (zeige IL12A Antikörper) beta 1 receptor is upregulated in both microglia and splenic macrophages.

9. IL-12 receptor beta 1 subunit plays an essential role in the activation and differentiation of Th1-type myelin oligodendrocyte glycoprotein (MOG)-specific autoreactive T cells in vivo.

10. IL-12 receptor beta 1 (Rbeta1) mediates IL-12 p40 (zeige IL12B Antikörper) homodimer (p80 (zeige COIL Antikörper))-dependent macrophage chemotaxis and inhibition of the p80 (zeige COIL Antikörper)-Rbeta1 interaction, a novel anti-inflammatory strategy to manipulate inflammation associated with respiratory viral infection.