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anti-Human Endothelin 1 Antikörper:
anti-Mouse (Murine) Endothelin 1 Antikörper:
anti-Rat (Rattus) Endothelin 1 Antikörper:
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Cow (Bovine) Polyclonal Endothelin 1 Primary Antibody für ELISA, IF - ABIN1582246
Jo, Ryu, Kim, Yeo, Kim, Choi, Song, Kang: Up-regulation of endothelial endothelin-1 expression prior to vasogenic edema formation in the rat piriform cortex following status epilepticus. in Neuroscience letters 2011
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Human Monoclonal Endothelin 1 Primary Antibody für IP, ELISA - ABIN560688
Ghoul, Serova, Astorgues-Xerri, Bieche, Bousquet, Varna, Vidaud, Phillips, Weill, Benhadji, Lokiec, Cvitkovic, Faivre, Raymond: Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. in Cancer research 2009
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Cow (Bovine) Polyclonal Endothelin 1 Primary Antibody für IHC, ELISA - ABIN1582247
Hayashi, Hosoe, Takahashi: Placental expression and localization of endothelin-1 system and nitric oxide synthases during bovine pregnancy. in Animal reproduction science 2012
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Dog (Canine) Monoclonal Endothelin 1 Primary Antibody für ICC, FACS - ABIN152685
Talati, West, Blackwell, Loyd, Meyrick: BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. in American journal of physiology. Lung cellular and molecular physiology 2010
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Human Monoclonal Endothelin 1 Primary Antibody für IHC (fro), IRMA - ABIN2473438
Papalambros, Sigala, Georgopoulos, Menekakos, Giatromanolaki, Bastounis, Sivridis: Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: correlation with symptoms and aortic diameter. in International journal of molecular medicine 2003
Study shows that cerebrovascular muscle cells can express endothelin-1 (ET-1). The production of ET-1 in cerebrovascular muscle cells stimulated by oxyhemoglobin occurs partially through the NF-[kappa]B signal pathway.
Plasma ET-1 levels of rabbits increased significantly in fluorinated groups compared with those in the control group.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.
Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.
High levels of ET-1 are closely associated with BBB (zeige ALMS1 Antikörper) disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH (zeige ACE Antikörper).
After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A (zeige EDNRA Antikörper)) receptor expression was upregulated in the basilar artery.
After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB (zeige NFKB1 Antikörper) activation. [endothelin-1; NFKB]
The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.
Endothelin-1 enhances nuclear Ca2 (zeige CA2 Antikörper)+ transients in atrial myocytes through Ins (zeige INS Antikörper)(1,4,5)P3-dependent Ca2 (zeige CA2 Antikörper)+ release from perinuclear Ca2 (zeige CA2 Antikörper)+ stores
sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (zeige MAPK14 Antikörper) kinase-mediated production of superoxide from NADPH oxidase (zeige NOX1 Antikörper) following ETA receptor activation
ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.
ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP (zeige HEBP1 Antikörper) release from neutrophils.
Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.
ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A (zeige EDNRA Antikörper)) receptors coupled to extracellular Ca(2 (zeige CA2 Antikörper)+) entry via VOC (L-type) and non-VOC channels.
Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI) model, but it is a likely target for understanding the observed enhanced vascular response to TBI.
interleukin-6 (zeige IL6 Antikörper), endothelin ET-1, and apoptotic Bak (zeige BAK1 Antikörper) and Bcl-XL (zeige BCL2L1 Antikörper) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
ET-1 elicits a different pattern of Src (zeige SRC Antikörper) family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.
Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.
study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1 (zeige ECE1 Antikörper)) acting via endothelin receptor A (zeige EDNRA Antikörper) in the control of luteolytic sensitivity in the pig
this study did not find any significant differences of ET-1 level between obstetric antiphospholipid syndrome and thrombotic antiphospholipid syndrome
Polymorphic variants of endothelin EDN (zeige RNASE2 Antikörper) (K198N) and endothelin receptor type A (zeige EDNRA Antikörper) genes EDN (zeige RNASE2 Antikörper) RA (C1222T, C70G, G231A) affected ET plasma concentrations. There was no association between the plasma endothelin levels and the risk factors for normal tension glaucoma.
high glucose and free fatty acids reduced NO and increased ET-1 levels induced by acetylcholine through the modulation of intracellular calcium concentrations and endothelial NO synthase (zeige NOS Antikörper) phosphorylation, events also reverted by hydroxytyrosol and polyphenol extract.
In both the acute and remission phase of thrombotic thrombocytopenic purpura we found increased CT-proET-1 and VWF (zeige VWF Antikörper) levels, while Factor H (zeige CFH Antikörper) levels decreased compared with healthy controls. In remission, however, the elevated CT-proET-1 levels showed a 22 % decrease when compared with the acute phase.
ET-1 increased NSCLC clonal growth, whereas BQ123, ZD4054, lapatinib or gefitinib inhibited proliferation. The results indicate that ET-1 may regulate NSCLC cellular proliferation in an EGFR (zeige EGFR Antikörper)- and HER2 (zeige ERBB2 Antikörper)-dependent manner
Data indicate that patients with systemic sclerosis (SSc (zeige CYP11A1 Antikörper)) displayed higher serum levels of VEGF (zeige VEGFA Antikörper), endothelin-1 and s-Fractalkine (zeige CX3CL1 Antikörper), and that the s-Fractalkine (zeige CX3CL1 Antikörper) levels positively correlated with CD34 (zeige CD34 Antikörper)(+)CD45 (zeige PTPRC Antikörper)(-) endothelial progenitor cells (EPC (zeige TCF21 Antikörper)) numbers.
Endothelin-1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention
we could provide evidence that established stress-related biomarkers ET-1, MCP-1 (zeige CCL2 Antikörper), CGA (zeige CGA Antikörper) were differentially regulated among patients with AF compared to healthy controls.
Two END1 (zeige VPS11 Antikörper) polymorphisms do not appear to affect the development of hypertension in the Chinese population.
TWEAK (zeige TNFSF12 Antikörper) may stimulate endothelial ET-1 synthesis, through the up-regulation of ECE-1 (zeige ECE1 Antikörper).
strial capillary basement membrane thickening results in hypoxic stress further elevating extracellular matrix and ET-1 gene expression, exacerbating strial pathology
c-Src tyrosine kinase (zeige CSK Antikörper) mediates high glucose-induced endothelin-1 expression
SIX1 (zeige SIX1 Antikörper) regulates dorsal arch development not only by inducing dorsal Jag1 (zeige JAG1 Antikörper) expression but also by inhibiting endothelin 1 (Edn1) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA (zeige EDNRA Antikörper) signaling.
NOX4 (zeige NOX4 Antikörper)-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 production.
in normal tissues the tandem of serine carboxypeptidases, Scpep1 (zeige SCPEP1 Antikörper) and CathA likely constitutes an important part of the physiological mechanism responsible for the balanced elimination of heightened levels of ET-1 that otherwise would accumulate in tissues and consequently contribute to development of the hyper-proliferative corneal dystrophy and abnormal skin thickening
Newborn endothelial cells express high levels of ET-1 peptides, rapidly release ET-1 in response to endothelial stimulation, and initiate ET-1-mediated endothelium-dependent constriction
cellular and molecular mechanisms of ET-1 action in periodontitis
Taken together, these data indicate that during high-salt feeding, the autocrine actions of ET-1 via upregulation of the ETB (zeige EDNRB Antikörper) receptor are critical for IMCD NO production, facilitating inhibition of ion reabsorption.
reduced lung levels of PPARgamma (zeige PPARG Antikörper) and increased levels of microRNA-27a (miR (zeige MLXIP Antikörper)-27a), v-ets (zeige ETS1 Antikörper) avian erythroblastosis virus E26 oncogene (zeige RAB1A Antikörper) homolog 1 (ETS1 (zeige ETS1 Antikörper)), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 (zeige PECAM1 Antikörper) and E selectin (zeige SELE Antikörper)).
Phylogenetic analysis of conserved grhl (zeige GHRL Antikörper)-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 (zeige GRHL3 Antikörper) target gene, and this was confirmed by chromatin precipitation assays in embryos.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Data suggest that edn1/ednraa (zeige EDNRA Antikörper) (endothelin-1/endothelin-1 receptor type A (zeige EDNRA Antikörper)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase (zeige DNAH8 Antikörper) in zebrafish embryonic skin.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
activation of Endothelin-1 signaling in craniofacial patterning
Edn1 from the pharyngeal ectoderm signals through Ednra (zeige EDNRA Antikörper) proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.
EDN-1 may be involved in the protection of sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct, supporting sperm survival until fertilization
Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2 (zeige EDN2 Antikörper), EDN3 (zeige EDN3 Antikörper)) and EDN (zeige RNASE2 Antikörper)-converting enzymes (ECE1 (zeige ECE1 Antikörper), ECE2 (zeige ECE2 Antikörper)) are expressed in epithelial cells; EDN (zeige RNASE2 Antikörper) receptors (EDNRA (zeige EDNRA Antikörper), EDNRB (zeige EDNRB Antikörper)) are present in smooth-muscle. Expression of EDN1, EDN2 (zeige EDN2 Antikörper), and ECE2 (zeige ECE2 Antikörper) is highest on day of ovulation. EDN (zeige RNASE2 Antikörper)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (zeige NOX1 Antikörper)-PKCalpha (zeige PKCa Antikörper)-p(38)MAPK (zeige MAPK1 Antikörper) and NFkappaB-MT1MMP (zeige MMP14 Antikörper) signaling pathways along with a marked decrease in TIMP-2 (zeige TIMP2 Antikörper) expression in the cells
We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 (zeige PLA2G4A Antikörper) activity in the cell membrane.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS (zeige NOS Antikörper) in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.
Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels
prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis
LOX-1 (zeige OLR1 Antikörper) and CD40 (zeige CD40 Antikörper) synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
Elevated local expression of ET-1 and Ednra/Ednrb (zeige EDNRB Antikörper) during the peri (zeige PLIN1 Antikörper)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.
This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.
A new role for et-1 signaling during early neural crest specification is reported.
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
, gene for endothelin
, endothelin 1
, preproendothelin 1
, endothelin 1 L homeolog