FBXO11 Produkte
(F-Box Protein 11 (FBXO11))
Kategorien
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010].
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Ausgewählte FBXO11 Kategorien
FBXO11 Antikörper
High quality antibodies with extensive validation data.
FBXO11 ELISA Kits
Reliable ELISA kits for a wide range of species.
FBXO11 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene FBXO11 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN566432
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
- (2)
Kat. Nr.
ABIN1386847
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IF
Validierungen
- (2)
Kat. Nr.
ABIN7261998
Menge
200 μL
Datenblatt
Datenblatt
Empfohlene FBXO11 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Sheep
Analytical Method
Validierungen
Kat. Nr.
ABIN1773981
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN1743076
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Dog
Analytical Method
Validierungen
Kat. Nr.
ABIN1769085
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene FBXO11 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1353767
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3089172
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3121953
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren FBXO11 Produkten
: "Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs." in: Molecular cell, Vol. 74, Issue 6, pp. 1264-1277.e7, (2019) (PubMed).: "Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing." in: Nature cell biology, Vol. 17, Issue 1, pp. 31-43, (2014) (PubMed).
: "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation." in: Developmental cell, Vol. 28, Issue 6, pp. 697-710, (2014) (PubMed).
: "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase." in: Molecular cell, Vol. 49, Issue 6, pp. 1159-66, (2013) (PubMed).
: "FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas." in: Nature, Vol. 481, Issue 7379, pp. 90-3, (2012) (PubMed).
: "Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 100-5, (2008) (PubMed).
Synonyme und alternative Namen zu FBXO11
F-box protein 11 (FBXO11), F-box protein 11 (Fbxo11), F-box protein 11 L homeolog (fbxo11.L), F-box protein 11a (fbxo11a), F-box only protein 11 (CpipJ_CPIJ009919), F-box only protein 11 (CpipJ_CPIJ017549), F-box only protein 11 (Bm1_52225), hypothetical protein (LOAG_16571), F-box protein 11 (fbxo11), F-box protein 11 (LOC100115478), C80048, DKFZp459P2410, FBX11, fbxo11, FBXO11, Fbxo11, im:6906507, Jf, MGC84634, PRMT9, UBR6, VIT1, Vit1, wu:fj83f06, zgc:153171Bezeichner auf Proteinebene für FBXO11
- F-box only protein 11
- protein arginine N-methyltransferase 9
- ubiquitin protein ligase E3 component n-recognin 6
- vitiligo-associated protein 1
- vitiligo-associated protein VIT-1
- GENA 104
- jeff
- F-box protein 11
- fj83f06
- F-box only protein 11-like
- f-box only protein 11-like
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