FBXO11 Antikörper (AA 65-160)

Produktnummer ABIN1386847

Produktdetails anti-FBXO11 Antikörper

Target: FBXO11 (F-Box Protein 11 (FBXO11))

Bindungsspezifität: AA 65-160

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXO11 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FBXO11

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu FBXO11

Target: FBXO11 (F-Box Protein 11 (FBXO11))

Andere Bezeichnung: FBXO11 (FBXO11 Produkte)

Synonyme: FBX11 antikoerper, PRMT9 antikoerper, UBR6 antikoerper, VIT1 antikoerper, C80048 antikoerper, Jf antikoerper, Vit1 antikoerper, fbxo11 antikoerper, MGC84634 antikoerper, FBXO11 antikoerper, im:6906507 antikoerper, wu:fj83f06 antikoerper, zgc:153171 antikoerper, Fbxo11 antikoerper, DKFZp459P2410 antikoerper, F-box protein 11 antikoerper, F-box protein 11 L homeolog antikoerper, F-box protein 11a antikoerper, F-box only protein 11 antikoerper, hypothetical protein antikoerper, FBXO11 antikoerper, Fbxo11 antikoerper, fbxo11.L antikoerper, fbxo11a antikoerper, CpipJ_CPIJ009919 antikoerper, CpipJ_CPIJ017549 antikoerper, Bm1_52225 antikoerper, LOAG_16571 antikoerper, fbxo11 antikoerper, LOC100115478 antikoerper

Hintergrund:

Synonyms: UBR6, VIT1, FBX11, PRMT9, UG063H01, F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

Gen-ID: 80204

UniProt: Q86XK2

Pathways: Sensory Perception of Sound