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anti-Human BRD4 Antikörper:
anti-Mouse (Murine) BRD4 Antikörper:
anti-Rat (Rattus) BRD4 Antikörper:
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Human Polyclonal BRD4 Primary Antibody für ICC, IF - ABIN438710
Rahman, Sowa, Ottinger, Smith, Shi, Harper, Howley: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. in Molecular and cellular biology 2011
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Human Polyclonal BRD4 Primary Antibody für ICC, IF - ABIN4285227
Zuber, Shi, Wang, Rappaport, Herrmann, Sison, Magoon, Qi, Blatt, Wunderlich, Taylor, Johns, Chicas, Mulloy, Kogan, Brown, Valent, Bradner, Lowe, Vakoc: RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. in Nature 2011
Show all 2 Pubmed References
Human Polyclonal BRD4 Primary Antibody für ChIP, WB - ABIN2668492
Flajollet, Rachez, Ploton, Schulz, Gallais, Métivier, Pawlak, Leray, Issulahi, Héliot, Staels, Salbert, Lefebvre: The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors. in PLoS ONE 2013
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Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis
Our data strongly support the use of CCR2 (zeige CCR2 Antikörper) and CD180 (zeige CD180 Antikörper) mRNAs as whole blood pharmacodynamic (PD)biomarkers for BRD4 inhibitors, especially in situations where paired tumor biopsies are unavailable. In addition, they can be used as tumor-based PD biomarkers for hematologic tumors.
Study identified Brd4 as a novel proline hydroxylation substrate with nearly 60% stoichiometry under normoxia states and its hydroxylation level is enzymatically regulated.
Further analysis indicated that JQ1 inhibited the recruitment of BDR4 to the promoter complex of the Myc (zeige MYC Antikörper) and Ccnd1 (zeige CCND1 Antikörper) genes in rat thyroid follicular PCCL3 cells, resulting in decreased MYC (zeige MYC Antikörper) expression at the mRNA and protein levels to inhibit tumor cell proliferation
The Brd4 acetyllysine-binding protein of RelA (zeige NFkBP65 Antikörper) is involved in activation of polyomavirus JC.
BRD4 phosphorylation regulates HPV E2-mediated viral transcription and cellular MMP-9 (zeige MMP9 Antikörper) expression
conclude that BRD3 (zeige BRD3 Antikörper)/4 and the FLT3 (zeige FLT3 Antikörper)-TAK1 (zeige MAP3K7 Antikörper)/NF-kB pathways collectively control a set of targets that are critically important for the survival of human MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) cells
Diverse gastric cancer cell lines of Asian and Brazilian origins differ in BRD4 and c-MYC (zeige MYC Antikörper) expression levels and sensitivity to BET inhibitors.
Together, dual inhibition of BRD4 and PI3K (zeige PIK3CA Antikörper) by SF2523 suppresses human prostate cancer cell growth in vitro and in vivo.
peroxisome proliferator activated receptor alpha peroxisome proliferator-activated receptor alpha (zeige PPARA Antikörper) PPAR-alpha (zeige PPARA Antikörper) nuclear receptor subfamily 1 group C member 1 (zeige PPARA Antikörper) peroxisome proliferative activated receptor alpha (zeige PPARA Antikörper) peroxisome proliferator-activated nuclear receptor alpha variant 3 (zeige PPARA Antikörper)
Brd4 is involved in different steps of the papillomavirus life cycle. (Review)
Using compound selectivity engineering and CRISPR/Cas9 genome editing, distinct functions for Erk5 (zeige MAPK7 Antikörper) and Brd4 in pluripotency regulation of mouse embryonic stem cells have been revealed.
Long-term treatment with bromodomain-containing protein 4 (BRD4) inhibitors caused telomere shortening in both mouse and human cells, suggesting BRD4 plays a role in telomere maintenance in vivo.
Fmr1 (zeige FMR1 Antikörper) knockout (KO) mice show widespread changes in histone marks as well as transcriptional misregulation resulting in increased expression of many critical synaptic genes. Data suggest that one chromatin target of FMRP (zeige FMR1 Antikörper), the reader protein Brd4, appears to be significantly involved in this transcriptional disruption.
The functional domains of mouse BRD4 and its role in transcription are described. Review.
Brd2 (zeige BRD2 Antikörper) and Brd4 genetic transcription required for Th17 cell development and adaptive immunity.
These data provide a detailed mechanism for how activated NF-kappaB (zeige NFKB1 Antikörper) and BRD4 control epithelial-mesenchymal transition initiation and transcriptional elongation in model airway epithelial cells in vitro and in a murine pulmonary fibrosis model in vivo.
DOT1L (zeige DOT1L Antikörper), via dimethylated histone H3 (zeige HIST3H3 Antikörper) K79, facilitates histone H4 (zeige HIST1H4H Antikörper) acetylation, which in turn regulates the binding of BRD4 to chromatin in acute lymphoblastic leukemia.
Acute induction of genes related to lipid accumulation in the livers of mice force-fed with fructose is associated with the induction of histone acetylation and BRD4 binding around these genes
Both mouse and human BRD4 have intrinsic histone acetyltransferase (zeige HAT Antikörper) activity.
the interaction between BRD4 and Mediator has functional importance for gene-specific transcriptional activation and for acute myeloid leukemia (zeige BCL11A Antikörper) maintenance.
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15\;19)(q13\;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Bromodomain-containing protein 4B
, bromodomain-containing protein 4B
, bromodomain containing 4
, bromodomain-containing protein 4
, bromodomain 4
, bromodomain-containing protein 4-like
, bromodomain containing protein 4
, bromodomain-containing 4
, chromosome-associated protein
, bromodomain-containing 5
, fsh-like protein
, mitotic chromosome-associated protein