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BRD4 Produkte

(Bromodomain Containing 4, BRD4)

Kategorien

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15\;19)(q13\;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].

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Ausgewählte BRD4 Kategorien

BRD4 Antikörper

High quality antibodies with extensive validation data.

BRD4 ELISA Kits

Reliable ELISA kits for a wide range of species.

BRD4 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene BRD4 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
ReaktivitätCow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
ApplikationChIP, IF, WB
Validierungen
  • collections(4)
Kat. Nr.ABIN2780921
Menge100 μL
ReaktivitätHuman, Mouse, Rat
ApplikationELISA, ICC, IF, IHC, WB
Validierungen
  • collections(4)
Kat. Nr.ABIN6260309
Menge100 μL
ReaktivitätHuman
ApplikationIHC, ELISA
Validierungen
  • collections(3)
Kat. Nr.ABIN3030205
Menge0.4 mL

Empfohlene BRD4 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
ReaktivitätHuman
Analytical MethodQuantitative Sandwich ELISA
Validierungen
  • collections(1)
Kat. Nr.ABIN6954198
Menge96 tests
ReaktivitätHuman
Analytical MethodQuantitative Sandwich ELISA
Validierungen
  • collections(1)
Kat. Nr.ABIN6974896
Menge96 tests
ReaktivitätMouse
Analytical Method
Validierungen
Kat. Nr.ABIN1124204
Menge96 tests

Empfohlene BRD4 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
ReaktivitätHuman
SourceEscherichia coli (E. coli)
Validierungen
  • collections(2)
Kat. Nr.ABIN2669645
Menge100 μg
ReaktivitätHuman
SourceEscherichia coli (E. coli)
Validierungen
  • collections(2)
Kat. Nr.ABIN2669694
Menge100 μg
ReaktivitätHuman
SourceInsect Cells
Validierungen
  • collections(1)
Kat. Nr.ABIN3090073
Menge1 mg

Neueste Publikationen zu unseren BRD4 Produkten

Yamada, Honma, Mochizuki, Goda: "BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver." in: Metabolism: clinical and experimental, Vol. 65, Issue 10, pp. 1478-88, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB)

Surface, Fields, Subramanian, Behmer, Udeshi, Peach, Carr, Jaffe, Boyer: "H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs." in: Cell reports, Vol. 14, Issue 5, pp. 1142-55, 2016 (PubMed).

Zimmermann, Aguilera, Castellucci, Rossato, Costa, Lunardi, Ostuni, Girolomoni, Natoli, Bazzoni, Tamassia, Cassatella: "Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils." in: Nature communications, Vol. 6, pp. 6061, 2015 (PubMed). (Probematerial (Species): Human). Weitere Details: Chromatin Immunoprecipitation

Alekseyenko, Walsh, Wang, Grayson, Hsi, Kharchenko, Kuroda, French: "The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains." in: Genes & development, Vol. 29, Issue 14, pp. 1507-23, 2015 (PubMed).

Flajollet, Rachez, Ploton, Schulz, Gallais, Métivier, Pawlak, Leray, Issulahi, Héliot, Staels, Salbert, Lefebvre: "The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors." in: PLoS ONE, Vol. 8, Issue 6, pp. e64880, 2013 (PubMed).

Rahman, Sowa, Ottinger, Smith, Shi, Harper, Howley: "The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3." in: Molecular and cellular biology, Vol. 31, Issue 13, pp. 2641-52, 2011 (PubMed).

Zuber, Shi, Wang, Rappaport, Herrmann, Sison, Magoon, Qi, Blatt, Wunderlich, Taylor, Johns, Chicas, Mulloy, Kogan, Brown, Valent, Bradner, Lowe, Vakoc: "RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia." in: Nature, Vol. 478, Issue 7370, pp. 524-8, 2011 (PubMed).

Mertz, Conery, Bryant, Sandy, Balasubramanian, Mele, Bergeron, Sims: "Targeting MYC dependence in cancer by inhibiting BET bromodomains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 40, pp. 16669-74, 2011 (PubMed).

Powell, Smith, Sowa, Harper, Iftner, Stubenrauch, Howley: "NCoR1 mediates papillomavirus E8;E2C transcriptional repression." in: Journal of virology, Vol. 84, Issue 9, pp. 4451-60, 2010 (PubMed).

Gagnon, Joubert, Sénéchal, Fradet-Turcotte, Torre, Archambault: "Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4." in: Journal of virology, Vol. 83, Issue 9, pp. 4127-39, 2009 (PubMed).

Synonyme und alternative Namen zu BRD4

bromodomain containing 4 L homeolog (brd4.L), bromodomain containing 4 (BRD4), bromodomain containing 4 (brd4), bromodomain-containing protein 4 (LOC100409351), bromodomain containing 4 (Brd4), BRD4, brd4-b, Brd5, CAP, fb18g03, HUNK1, HUNKI, MCAP, WI-11513, wu:fb18g03

Gen-IDs für verschiedene Spezies

GENE ID SPEZIES
446381 Xenopus laevis
455794 Pan troglodytes
570531 Danio rerio
100062072 Equus caballus
100216259 Xenopus (Silurana) tropicalis
100409351 Callithrix jacchus
100463607 Ailuropoda melanoleuca
100074736 Ornithorhynchus anatinus
100352214 Oryctolagus cuniculus
100533540 Sus scrofa
100593625 Nomascus leucogenys
23476 Homo sapiens
484869 Canis lupus familiaris
614048 Bos taurus
57261 Mus musculus
362844 Rattus norvegicus

Bezeichner auf Proteinebene für BRD4

  • Bromodomain-containing protein 4B
  • bromodomain-containing protein 4B
  • bromodomain containing 4
  • bromodomain-containing protein 4
  • bromodomain 4
  • bromodomain-containing protein 4-like
  • bromodomain containing protein 4
  • bromodomain-containing 4
  • chromosome-associated protein
  • bromodomain-containing 5
  • fsh-like protein
  • mitotic chromosome-associated protein
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