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BRCC3 Produkte

(BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Kategorien

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011].

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Ausgewählte BRCC3 Kategorien

BRCC3 Antikörper

High quality antibodies with extensive validation data.

BRCC3 ELISA Kits

Reliable ELISA kits for a wide range of species.

BRCC3 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene BRCC3 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC
Validierungen
  • (4)
Kat. Nr. ABIN7158679
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC
Validierungen
  • (3)
Kat. Nr. ABIN7158678
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC, IHC (p)
Validierungen
  • (3)
Kat. Nr. ABIN462274
Menge 50 μL
Datenblatt Datenblatt

Empfohlene BRCC3 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN6954187
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN2945768
Menge 96 tests
Datenblatt Datenblatt

Empfohlene BRCC3 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3134114
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3090154
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7414093
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren BRCC3 Produkten

Xu, Moresco, Chang, Mukim, Smith, Diedrich, Yates, Jones: "SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy." in: PLoS pathogens, Vol. 14, Issue 5, pp. e1007071, (2018) (PubMed).

Li, Li, Yu, Zhang, Wang, Jia: "miR-3940-5p associated with genetic damage in workers exposed to hexavalent chromium." in: Toxicology letters, Vol. 229, Issue 1, pp. 319-26, (2014) (PubMed).

Chen, Arciero, Wang, Broccoli, Godwin: "BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation." in: Cancer research, Vol. 66, Issue 10, pp. 5039-46, (2006) (PubMed).

Dong, Hakimi, Chen, Kumaraswamy, Cooch, Godwin, Shiekhattar: "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair." in: Molecular cell, Vol. 12, Issue 5, pp. 1087-99, (2003) (PubMed).

Synonyme und alternative Namen zu BRCC3

BRCA1/BRCA2-containing complex subunit 3 (BRCC3), DEP domain containing 1B (depdc1b), BRCA1/BRCA2-containing complex subunit 3 (brcc3), BRCA1/BRCA2-containing complex, subunit 3 (Brcc3), BRCA1/BRCA2-containing complex subunit 3 L homeolog (brcc3.L), BRCC3, brcc3, BRCC36, brcc36, C6.1A, CXorf53, xtp1

Bezeichner auf Proteinebene für BRCC3

  • BRCA1/BRCA2-containing complex, subunit 3
  • c6.1A
  • BRCA1-A complex subunit BRCC36
  • BRCA1/BRCA2-containing complex subunit 3
  • BRCA1/BRCA2-containing complex subunit 36
  • BRISC complex subunit BRCC36
  • lys-63-specific deubiquitinase BRCC36
  • 6.1A protein
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