BRCC3 Protein (AA 2-316) (His-SUMO Tag)

Produktnummer ABIN5709149

Produktdetails

Target: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Protein-Typ: Recombinant

Proteineigenschaft: AA 2-316

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses BRCC3 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: AVQVVQAVQA VHLESDAFLV CLNHALSTEK EEVMGLCIGE LNDDTRSDSK FAYTGTEMRT VAEKVDAVRI VHIHSVIILR RSDKRKDRVE ISPEQLSAAS TEAERLAELT GRPMRVVGWY HSHPHITVWP SHVDVRTQAM YQMMDQGFVG LIFSCFIEDK NTKTGRVLYT CFQSIQAQKS SESLHGPRDF WSSSQHISIE GQKEEERYER IEIPIHIVPH VTIGKVCLES AVELPKILCQ EEQDAYRRIH SLTHLDSVTK IHNGSVFTKN LCSQMSAVSG PLLQWLEDRL EQNQQHLQEL QQEKEELMQE LSSLE

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Andere Bezeichnung: BRCC3 (BRCC3 Produkte)

Synonyme: CXorf53 Protein, BRCC3 Protein, xtp1 Protein, brcc3 Protein, BRCC36 Protein, brcc36 Protein, C6.1A Protein, BRCA1/BRCA2-containing complex subunit 3 Protein, DEP domain containing 1B Protein, BRCA1/BRCA2-containing complex, subunit 3 Protein, BRCA1/BRCA2-containing complex subunit 3 L homeolog Protein, BRCC3 Protein, depdc1b Protein, brcc3 Protein, Brcc3 Protein, brcc3.L Protein

Hintergrund: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically roves 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex

Molekulargewicht: 51.9 kDa

UniProt: P46736

Pathways: Positive Regulation of Response to DNA Damage Stimulus