BRD4 Antikörper (Bromodomain Containing 4) (C-Term)

Details for Product anti-BRD4 Antibody No. ABIN2780921, Anbieter: Anmelden zum Anzeigen
Antigen
  • brd4-b
  • BRD4
  • fb18g03
  • wu:fb18g03
  • CAP
  • HUNK1
  • HUNKI
  • MCAP
  • Brd5
  • WI-11513
  • bromodomain containing 4 L homeolog
  • bromodomain containing 4
  • bromodomain-containing protein 4
  • brd4.L
  • BRD4
  • brd4
  • LOC100409351
  • Brd4
Epitop
C-Term
23
17
17
15
11
8
8
3
3
2
2
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
106
38
20
7
6
6
6
5
4
2
1
1
Wirt
Kaninchen
101
5
1
Klonalität
Polyklonal
Konjugat
Dieser BRD4 Antikörper ist unkonjugiert
7
7
6
6
6
6
1
1
1
1
1
1
1
1
1
1
1
Applikation
Chromatin Immunoprecipitation (ChIP), Immunofluorescence (IF), Western Blotting (WB)
76
50
50
35
27
24
5
4
3
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human BRD4
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN973879.
Sequenz EIEIDFETLK PSTLRELERY VTSCLRKKRK PQAEKVDVIA GSSKMKGFSS
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against BRD4. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung BRD4 (BRD4 Antibody Abstract)
Hintergrund BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting.The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15,19)(q13,p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Alias Symbols: CAP, HUNKI, MCAP, HUNK1
Protein Interaction Partner: AFF1, CDK9, CCNT1, STAT3, JMJD6, TCERG1, HEXIM1, RN7SK, PRPF40A, vif, RPL6, MYC, MLLT1, ELAVL1, SUMO2, UBC, YWHAZ, KAT8, C8orf33, MESDC2, HIST1H4A, HIST1H3A, YWHAE, MED1, EP300, KDM5B, C7orf25, CHFR, CLDN1, RFC1, RFC4, HIST2H3C, HIST2H4A, MED12, MED24, ME
Protein Size: 722
Molekulargewicht 80 kDa
Gen-ID 23476
NCBI Accession NM_014299, NP_055114
Pathways Chromatin Binding
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 722 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Immunofluorescence (IF) image for anti-Bromodomain Containing 4 (BRD4) (C-Term) antibody (ABIN2780921) Sample Type: HeLa
Primary Antibody Dilution: 4 µg/mL
Secondary Antibody: ...
Chromatin Immunoprecipitation (ChIP) image for anti-Bromodomain Containing 4 (BRD4) (C-Term) antibody (ABIN2780921) Chromatin Immunoprecipitation (ChIP) Using BRD4 Antibody - C-terminal region (ARP3907...
Allgemeine Veröffentlichungen Schweiger, You, Howley: "Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function." in: Journal of virology, Vol. 80, Issue 9, pp. 4276-85, 2006 (PubMed).

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