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BCL6 forms a complex with BCL6 corepressor (BCoR (zeige BCOR ELISA Kits)) on the promoters of selected Notch (zeige NOTCH1 ELISA Kits) target genes such as enhancer of split related 1.
The balance between CD4 (zeige CD4 ELISA Kits)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (zeige TCF7 ELISA Kits) (encoding TCF-1 (zeige HNF1A ELISA Kits)) and by the expression of the inhibitory receptors PD-1 (zeige PDCD1 ELISA Kits) and LAG3 (zeige LAG3 ELISA Kits).
Study provides evidence for an essential role of Bcl6 in the complex regulation of gene transcription during early adipogenesis. The action of Bcl6 is at least partially mediated by the direct transcriptional activation of STAT1 (zeige STAT1 ELISA Kits).
These data describe a novel regulatory mechanism through which STAT3 (zeige STAT3 ELISA Kits) and the Ikaros (zeige IKZF1 ELISA Kits) zinc finger transcription factors Aiolos (zeige IKZF3 ELISA Kits) and Ikaros (zeige IKZF1 ELISA Kits) cooperate to regulate Bcl-6 expression.
Our data reveal a regulatory role of BCL6 in inhibiting antiviral resistance factors in follicular Th cells
data provide a novel mechanism for positive control of gene expression by Bcl6, and illuminate how Bcl6 and Blimp1 (zeige PRDM1 ELISA Kits) control follicular helper T cell differentiation
both mouse and human B cells, IFN-gamma (zeige IFNG ELISA Kits) synergized with B cell receptor, toll (zeige TLR4 ELISA Kits)-like receptor, and/or CD40 (zeige CD40 ELISA Kits) activation signals to promote cell-intrinsic expression of the GC master transcription factor, B cell lymphoma 6 protein.
observations reveal that KLF6 (zeige KLF6 ELISA Kits) repress BCL6 to enhance macrophage inflammatory gene expression and function.
synergistic activity of Card11 (zeige CARD11 ELISA Kits) mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model
Bcl6, by interacting with the co-factors NcoR2 and HDAC3 (zeige HDAC3 ELISA Kits), plays a pivotal role in controlling IRF7 (zeige IRF7 ELISA Kits) induction and antiviral signaling priming.
Bcl6 promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (zeige STAT5A ELISA Kits) axis.
We show that human follicular lymphomas are dependent on BCL6
Aberrant BCL6 expression was strongly associated with poor reproductive outcomes in IVF (zeige SCN5A ELISA Kits) cycles in women with unexplained infertility.
EBNA3C inhibits the transcriptional activity of the Bcl6 promoter through interaction with the cellular protein IRF4 (zeige IRF4 ELISA Kits).
Data show that MYC (zeige MYC ELISA Kits), BCL2 (zeige BCL2 ELISA Kits) and BCL6 translocation had no prognostic impact with respect to progression free survival (PFS) or overall survival (OS).
Data suggest that B-cell CLL/lymphoma 6 is a promising candidate as a single diagnostic biomarker for detection of endometriosis in women with otherwise unexplained infertility and may be associated with endometrial dysfunction, including progesterone resistance.
The aim of this study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, GATA-3 (zeige GATA3 ELISA Kits) and Bcl-6 in bladder cancer in Tunisian patients.
analysis of role of BCL6 in maintaining activated B cell diffuse large B cell lymphoma reveals that ABC (zeige ABCB6 ELISA Kits)-DLBCL is a BCL6-dependent disease that can be targeted by rationally designed inhibitors that exceed the binding affinity of natural BCL6 ligands
Results provide evidence that BCL6 overexpression is involved in genomic instability in multiple myeloma cells.
the high expressions of BCL6 and Lewis y antigen are associated with development, high tumor burden, and worse prognosis of ovarian cancer and targeting BCL6 could be a novel therapeutic strategy for ovarian cancer treatment.
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
B-cell CLL/lymphoma 6
, B-cell CLL/lymphoma 6 (zinc finger protein 51)
, B-cell lymphoma 6 protein
, zinc finger protein 51
, B-cell leukemia/lymphoma 5
, B-cell leukemia/lymphoma 6
, B-cell lymphoma 6 protein homolog
, B-cell lymphoma 5 protein
, B-cell lymphoma 6 protein transcript
, cys-his2 zinc finger transcription factor
, lymphoma-associated zinc finger gene on chromosome 3
, protein LAZ-3
, zinc finger and BTB domain-containing protein 27
, zinc finger transcription factor BCL6S