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Human Polyclonal PDE4B Primary Antibody für IP, ELISA - ABIN2750915
Vang, Housley, Dong, Basole, Ben-Sasson, Kream, Epstein, Clark, Brocke: Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. in The Biochemical journal 2013
HTT (zeige HTT Antikörper) forms a ternary protein complex with the scaffolding protein DISC1 (zeige DISC1 Antikörper) and cAMP-degrading phosphodiesterase 4 (PDE4 (zeige PDE4A Antikörper)) to regulate PDE4 (zeige PDE4A Antikörper) activity.
Low PDE4B expression is associated with sepsis.
PDE4B gene may be involved in the testicular abnormalities of men with DS and cryptorchidism.
This meta-analysis suggests that PDE4B SNPs are genetically associated with susceptibility to schizophrenia.
Our results suggest that PDE4B does not play an important role during the chemotactic response of human neutrophils
Our results support previously reported association of PDE4B variations with schizophrenia in other populations.
analysis of the mechanism underlying synergistic up-regulation of PDE4B2 via a cross-talk between PKA-Cbeta and p65 (zeige GORASP1 Antikörper)
ototopical post-inoculation administration of a PDE4 (zeige PDE4A Antikörper) inhibitor suppresses inflammation in this animal model, thus demonstrating the therapeutic potential of targeting PDE4 (zeige PDE4A Antikörper)
PDE4B was found to be highly expressed in CD4 (zeige CD4 Antikörper)+ lymphoid cancer cells, which suggests that it may represent a physiological role unique to the CD8 (zeige CD8A Antikörper)+ and lymphoid cancer cells and thus might represent a target for treatment of certain lymphoid diseases
Short Disrupted-in-Schizophrenia (DISC)1 splice variants show reduced or no binding to nudE nuclear distribution E homolog (NDEL)1 and PDE4B proteins but fully interact with fasciculation/elongation zeta (FEZ)1 and glycogen synthase kinase 3 GSK3beta.
These results demonstrate that the alcohol- induced increase in hepatic Pde4 (zeige PDE4A Antikörper), specifically Pde4b expression, and compromised cAMP signalling predispose the liver to impaired fatty acid oxidation and the development of steatosis.
PDE4B phosphorylated by AMPK (zeige PRKAA1 Antikörper) at Ser304 is important for activation.
Lymphomas developing in a Pde4b-null background display significantly lower microvessel density in association with lower VEGF (zeige VEGFA Antikörper) levels and PI3K/AKT (zeige AKT1 Antikörper) activity.
Genetic variations in DISC1 influence formation of biochemical complex with PDE4 and GSK-3 and strengthen the possibility of synergistic interactions between these proteins.
PDE4B-deficient mice display impaired reversal learning in the Morris water maze compared to wild-type littermates.
Results identify PDE4B in the CaV1.2 (zeige CACNA1C Antikörper) complex as a critical regulator of ICa during beta-AR stimulation and suggest that distinct PDE4 (zeige PDE4A Antikörper) subtypes are important for normal regulation of calcium-induced calcium release in cardiomyocytes.
Findings demonstrate that PDE4D (zeige PDE4D Antikörper) and PDE4B have specialized functions in mouse embryonic fibroblasts with PDE4B controlling cAMP in a discrete subdomain near the plasma membrane.
induction is esssential for LPS (zeige TLR4 Antikörper)-activated tnf-alpha (zeige TNF Antikörper) responses
PDE4B mediates the antipsychotic effects of rolipram in conditioned avoidance responding; the PDE4B-regulated cyclic adenosine monophosphate signaling pathway may play a role in the pathophysiology and pharmacotherapy of psychosis
the PDE4B subfamily is involved in signaling pathways that contribute to anxiogenic-like effects on behavior.
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, cAMP-specific 3',5'-cyclic phosphodiesterase 4B
, cAMP-specific phosphodiesterase-4 B isoform
, dunce-like phosphodiesterase E4
, phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
, phosphodiesterase 4B
, phosphodiesterase 4B, cAMP-specific a
, 3',5'-cyclic AMP phosphodiesterase
, Phosphodiesterase 4B cAMP-specific (dunce
, Phosphodiesterase 4B, cAMP-specific (dunce