PDE4B Antikörper (Middle Region)

Produktnummer ABIN2786603

Produktdetails anti-PDE4B Antikörper

Target: PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schwein, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE4B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QDILDTLEDN RNWYQSMIPQ SPSPPLDEQN RDCQGLMEKF QFELTLDEED

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 83%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against PDE4B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PDE4B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 564 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PDE4B Antikörper (ABIN2786603)

Fatemi, King, Reutiman, Folsom, Laurence, Lee, Fan, Paciga, Conti, Menniti: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." in: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).

Details zu PDE4B

Target: PDE4B (phosphodiesterase 4B, cAMP-Specific (PDE4B))

Andere Bezeichnung: PDE4B (PDE4B Produkte)

Synonyme: dpde4 antikoerper, pde4b5 antikoerper, pdeivb antikoerper, Dpde4 antikoerper, R74983 antikoerper, dunce antikoerper, PDE4/IVb antikoerper, Pde4B1 antikoerper, Pde4B2 antikoerper, Pde4B3 antikoerper, Pde4B4 antikoerper, DPDE4 antikoerper, PDE4B5 antikoerper, PDEIVB antikoerper, phosphodiesterase 4B antikoerper, phosphodiesterase 4B, cAMP specific antikoerper, phosphodiesterase 4B S homeolog antikoerper, pde4b antikoerper, PDE4B antikoerper, Pde4b antikoerper, pde4b.S antikoerper

Hintergrund: The specific function of this protein remains unknown.This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: DKFZp686F2182, DPDE4, MGC126529, PDE4B5, PDEIVB
Protein Interaction Partner: MAGEA11, RCBTB2, APOA1, ALB, PAFAH1B1, UBC, DISC1, PRKACA,
Protein Size: 564

Molekulargewicht: 64 kDa

Gen-ID: 5142

NCBI Accession: NM_001037339, NP_001032416

UniProt: Q5TEK5

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction