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Human Polyclonal GNB2L1 Primary Antibody für IHC, IHC (p) - ABIN4892013
Yang, Pu, Qin, You, Ke: Characterization of receptor of activated C kinase 1 (RACK1) and functional analysis during larval metamorphosis of the oyster Crassostrea angulata. in Gene 2014
RACK1 emerges as an important marker of malignancy which may contribute to progress in the diagnosis of melanomas in both human and veterinary medicine.[RACK1]
The data of this study suggested that point contacts are a targeted site of local translation within growth cones, and RACK1 is a critical member of the point contact complex and necessary for appropriate neural development.
A sequential and coordinated activation of ERK (zeige EPHB2 Antikörper), JNK (zeige MAPK8 Antikörper) and STAT3 (zeige STAT3 Antikörper) with RACK1 is shown to accelerate aggressive melanoma development in vivo.
Leads to the enhanced and previously un-described interaction of RACK1 and TCTP (zeige TPT1 Antikörper).
urther investigation indicated that p205 may disturb the formation of Runx2 (zeige RUNX2 Antikörper)/Ids (zeige IDS Antikörper) complex and free more Runx2 (zeige RUNX2 Antikörper) to induce the differentiation process. Taken together, our findings demonstrated for the first time that p205 functions as an activator in osteoblast differentiation.
RACK1 competes with Rab40C (zeige RAB40C Antikörper) for binding to the ANKR2 domain of Varp (zeige ANKRD27 Antikörper) and regulates dendrite outgrowth through stabilization of Varp (zeige ANKRD27 Antikörper) in mouse melanocytes
Data show that receptor for activated C-kinase 1 (RACK1) and vascular endothelial growth factor (VEGF (zeige VEGF Antikörper)) expression is up-regulated after choroidal neovascularization (CNV) formation.
RACK1 is a novel factor required for adipocyte differentiation.
deficit of RACK1 in hippocampus impairs the ability of learning and memory in mice via up regulating autophagy
RACK1 plays an important role in the maintenance of morphine conditioned place preference, likely via activation of ERK (zeige EPHB2 Antikörper)-CREB (zeige CREB1 Antikörper) pathway in hippocampus.
Thr50 phosphorylation of RACK1 enhances its direct binding to Vps15, Atg14L, and Beclin 1 (zeige BECN1 Antikörper), thereby promoting the assembly of the autophagy-initiation complex.
These results suggest that RACK1 promotes cell growth and invasion and inhibits the senescence and apoptosis in cervical cancer cells probably by affecting the p53 (zeige TP53 Antikörper) pathway.
The present findings indicate that RACK1 silencing attenuates renal fibrosis by suppressing the activation of TGF-beta1 (zeige TGFB1 Antikörper)/Smad3 (zeige SMAD3 Antikörper) signaling pathway in HK-2 (zeige HK2 Antikörper) cells. Thus, RACK1 may serve as a novel regulator of renal fibrosis.
RACK1 associates with MOAP-1 (zeige MOAP1 Antikörper) via electrostatic associations similar to those observed between MOAP-1 (zeige MOAP1 Antikörper)/RASSF1A (zeige RASSF1 Antikörper) and MOAP-1 (zeige MOAP1 Antikörper)/TNF-R1 (zeige TNFRSF1A Antikörper). These events illustrate the complex nature of MOAP-1 (zeige MOAP1 Antikörper) regulation and characterizes the important role of the scaffolding protein, RACK1, in influencing MOAP-1 (zeige MOAP1 Antikörper) biology.
data provided evidence that increased Rack1-mediated upregulation of PKC (zeige PRRT2 Antikörper) kinase activity may be responsible for the development of chemoresistance in T-ALL-derived cell line potentially by reducing FEM1b (zeige FEM1B Antikörper) and Apaf-1 (zeige APAF1 Antikörper) level.
Data indicate that RACK1 increases interactions between Akt (zeige AKT1 Antikörper) and MCM7 (zeige MCM7 Antikörper) and promotes Akt (zeige AKT1 Antikörper)-dependent MCM7 (zeige MCM7 Antikörper) phosphorylation, which in turn increases MCM7 (zeige MCM7 Antikörper) binding to chromatin and miniature chromosome maintenance (MCM) complex formation.
the depletion of ribosomal RACK1 alters the capacity of the ribosome to translate specific mRNAs, resulting in selective translation of mRNAs of genes for non-canonical autophagy induction.
This work has significantly advanced our understanding of the RACK1/PP2A (zeige PPP2R4 Antikörper) complex and suggests a pro-carcinogenic role for the RACK1/PP2A (zeige PPP2R4 Antikörper) interaction. This work suggests that approaches to target the RACK1/PP2A (zeige PPP2R4 Antikörper) complex are a viable option to regulate PP2A (zeige PPP2R4 Antikörper) activity and identifies a novel potential therapeutic target in the treatment of breast cancer.
Our analysis shows that most of the interaction partners with putative regulatory functions have binding sites that are available on ribosomal RACK1, supporting the role of RACK1 as a ribosomal signaling hub.
This supports PDE4D5 and RACK1 as potential regulators of cell adhesion, spreading and migration through the non-classical exchange protein activated by cyclic AMP (EPAC1)/Rap1 signalling route
In this review we summarize this evidence and examine the mechanisms that underlie the contribution of RACK1 to the various stages of cell migration and invasion.
Rack1 has a dominant-negative effect on Vangl2 (zeige VANGL2 Antikörper) localization and gastrulation.
These results suggest that PKCepsilon (zeige PRKCE Antikörper) signaling in the basal airway cell may involve RACK1; however, PKCepsilon (zeige PRKCE Antikörper) regulation in ciliated cells uses RACK1-independent pathways.
this study unveils novel defense mechanisms exist for C. elegans in facilitating enhanced immunity by RACK-1 against Shigella flexneri infection
Lactobacillus casei pretreatment triggers the TLR mediated and rack-1 dependent p38 MAPK (zeige MAPK14 Antikörper) signaling pathway in nematodes. rack-1 is necessary in activating the p38 MAPK (zeige MAPK14 Antikörper) pathway by Lactobacillus casei.
RACK-1 controls the biogenesis of a subset of miRNAs, including let-7, and in this way plays a role in the heterochronic gene pathway during C. elegans development.
RACK1 can contribute to the recruitment of miRISC to the site of translation, and support a post-initiation mode of miRNA-mediated gene repression.
show that depletion of Caenorhabditis elegans RACK-1, which leads to short astral microtubules during prometaphase, specifically affects maintenance of cortical PAR (zeige AFG3L2 Antikörper) domains and Dynamin localization
These studies pinpoint RACK-1 as a component of a novel signaling pathway involving Rac (zeige AKT1 Antikörper) GTPases and UNC-115/abLIM (zeige ABLIM1 Antikörper).
suggest a mechanism by which RACK-1 directs the dynactin (zeige DCTN1 Antikörper)-dependent redistribution of recycling endosomes during the cell cycle
may act as a receptor for activated protein kinase C
guanine nucleotide binding protein, beta 2, related sequence 1
, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
, G-beta-like protein
, guanine nucleotide-binding protein beta subunit
, activated protein kinase C receptor
, guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1
, guanine nucleotide binding protein related
, guanine nucleotide binding protein, beta-2, related sequence 1
, guanine nucleotide-binding protein subunit beta-2-like 1
, receptor for activated C kinase
, receptor of activated protein kinase C 1
, guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1
, guanine nucleotide binding protein, beta polypeptide 2-like 1
, protein kinase C receptor
, receptor for activated protein kinase C
, cell proliferation-inducing gene 21 protein
, guanine nucleotide-binding protein subunit beta-like protein 12.3
, human lung cancer oncogene 7 protein
, lung cancer oncogene 7
, proliferation-inducing gene 21
, protein homologous to chicken B complex protein, guanine nucleotide binding
, receptor for activated C kinase 1
, receptor of activated protein kinase C
, Guanine nucleotide-binding protein beta subunit2-like 1
, MHC B complex protein 12.3
, guanine nucleotide binding 12.3
, guanine nucleotide-binding protein beta subunit 2-like 1
, G-beta like protein