GNB2L1 Antikörper (AA 2-317)

Produktnummer ABIN3042427

Produktdetails anti-GNB2L1 Antikörper

Target: GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1))

Bindungsspezifität: AA 2-317

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GNB2L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Receptor of activated protein C kinase 1(RACK1) detection. Tested with WB in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Receptor of activated protein C kinase 1(RACK1) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: receptor for activated C kinase 1
Protein Name: Receptor of activated protein C kinase 1

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human RACK1 recombinant protein (Position: T2-R317). Human RACK1 shares 100% amino acid (aa) sequence identity with both mouse and rat RACK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for RACK1 is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-GNB2L1 Antikörper (ABIN3042427)

Jin, Mu, Wang, Liu, Wan, Xiong, Zhang, Zhou, Li: "Overexpressed RACK1 is positively correlated with malignant degree of human colorectal carcinoma." in: Molecular biology reports, Vol. 41, Issue 5, pp. 3393-9, (2015) (PubMed).

Details zu GNB2L1

Target: GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1))

Andere Bezeichnung: GNB2L1 (GNB2L1 Produkte)

Synonyme: MGC53289 antikoerper, GNB2L1 antikoerper, AL033335 antikoerper, GB-like antikoerper, Gnb2-rs1 antikoerper, Rack1 antikoerper, p205 antikoerper, RACK1 antikoerper, H12.3 antikoerper, HLC-7 antikoerper, PIG21 antikoerper, rack1 antikoerper, wu:fb80d08 antikoerper, wu:fk65d12 antikoerper, gnb2-rs1 antikoerper, h12.3 antikoerper, hlc-7 antikoerper, pig21 antikoerper, C12-3 antikoerper, c12.3 antikoerper, guanine nucleotide binding protein, beta 2, related sequence 1 antikoerper, receptor for activated C kinase 1 antikoerper, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 antikoerper, receptor for activated C kinase 1 L homeolog antikoerper, Guanine nucleotide-binding protein subunit beta-2-like 1 antikoerper, gnb2l1 antikoerper, RACK1 antikoerper, Rack1 antikoerper, rack1.L antikoerper, rack-1 antikoerper

Hintergrund: Guanine nucleotide-binding protein subunit beta-2-like 1, also known as RACK1 is a 32 kDa protein that in humans is encoded by the GNB2L1 gene. It is mapped to 5q35.3. GNB2L1 is a major component of translating ribosomes, which harbor significant amounts of PKC. This gene can provide a physical and functional link between PKC signaling and ribosome activation. GNB2L1 is also a mediator of agonist-induced Ca(2+) release. What's more, GNB2L1 is an essential component of an oxygen-independent mechanism for regulating HIF1A stability. Overexpression of GNB2L1 and PKC-alpha suppressed CLOCK-BMAL1 transcriptional activity, and GNB2L1 stimulated phosphorylation of BMAL1 by PKC-alpha in vitro.

Synonyms: Cell proliferation-inducing gene 21 protein antibody|GBLP_HUMAN antibody|Gnb2 rs1 antibody|Gnb2-rs1 antibody|GNB2L1 antibody|Gnb2rs1 antibody|Guanine nucleotide binding protein (G protein) beta polypeptide 2 like 1 antibody|Guanine nucleotide binding protein beta polypeptide 2 like 1 antibody|Guanine nucleotide binding protein beta subunit 2 like 1 antibody|Guanine nucleotide binding protein beta subunit like protein 12.3 antibody|Guanine nucleotide binding protein subunit beta 2 like 1 antibody|Guanine nucleotide binding protein subunit beta like protein 12.3 antibodyGuanine nucleotide-binding protein subunit beta-2-like 1 antibody|Guanine nucleotide-binding protein subunit beta-like protein 12.3 antibody|H12.3 antibody|HLC 7 antibody|HLC-7 antibody|HLC7 antibody|Human lung cancer oncogene 7 protein antibody|Lung cancer oncogene 7 antibody|OTTHUMP00000223704 antibody|OTTHUMP00000223870 antibody|OTTHUMP00000223891 antibody|OTTHUMP00000223893 antibody|OTTHUMP00000223900 antibody|OTTHUMP00000223902 antibody|OTTHUMP00000223930 antibody|OTTHUMP00000223931 antibody|PIG 21 antibody|PIG21 antibody|Proliferation inducing gene 21 antibody|Protein homologous to chicken B complex protein guanine nucleotide binding antibody|RACK 1 antibody|RACK1 antibody|Receptor for activated C kinase antibody|Receptor for activated C kinase 1 antibody|Receptor of activated protein kinase C 1 antibody

Gen-ID: 10399

UniProt: P63244

Pathways: cAMP Metabolic Process, Positive Regulation of Endopeptidase Activity