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Human Monoclonal PTGS2 Primary Antibody für IHC (p) - ABIN1687606
Yang, Hsu, Meng, Su: Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis. in Arthritis research & therapy 2015
Show all 29 Pubmed References
Human Monoclonal PTGS2 Primary Antibody für IHC (p) - ABIN1687611
Carvalho, Pires, Prada, Ferreira, Queiroga: Positive Interplay Between CD3+ T-lymphocytes and Concurrent COX-2/EGFR Expression in Canine Malignant Mammary Tumors. in Anticancer research 2015
Show all 24 Pubmed References
Human Polyclonal PTGS2 Primary Antibody für IHC (fro), IHC (p) - ABIN3044296
Guo, Li, Wu, Gong, Lu, Shi: Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2010
Show all 15 Pubmed References
Human Polyclonal PTGS2 Primary Antibody für IHC, IHC (p) - ABIN152112
Chu, Yeh, Lin, Jung, Ma, Wang, Wu, Shiu, Chen: Deletion of the FHL2 gene attenuating neovascularization after corneal injury. in Investigative ophthalmology & visual science 2008
Show all 14 Pubmed References
Human Polyclonal PTGS2 Primary Antibody für IHC (p), WB - ABIN3044295
Liu, Yan, Li, Yin, Sun, Kou, Ye, Ferns, Liu, Liu: Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/?-catenin signaling pathway. in Journal of ovarian research 2014
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Human Polyclonal PTGS2 Primary Antibody für IF (p), IHC (p) - ABIN672471
Gao, Wen, Yang, Lu, Tong, Huang, Liu, Tang: Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. in PLoS ONE 2013
Show all 9 Pubmed References
Chicken Monoclonal PTGS2 Primary Antibody für IF, IP - ABIN967823
Giroux, Descoteaux: Cyclooxygenase-2 expression in macrophages: modulation by protein kinase C-alpha. in Journal of immunology (Baltimore, Md. : 1950) 2000
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Chicken Monoclonal PTGS2 Primary Antibody für WB - ABIN967824
Hla, Neilson: Human cyclooxygenase-2 cDNA. in Proceedings of the National Academy of Sciences of the United States of America 1992
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Chicken Monoclonal PTGS2 Primary Antibody für IF, IP - ABIN967822
Marrogi, Pass, Khan, Metheny-Barlow, Harris, Gerwin: Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. in Cancer research 2000
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Human Polyclonal PTGS2 Primary Antibody für ELISA, WB - ABIN257712
George, Morrow, Xu, Yi, Holmes, Wu, Li, Protter, Oz, Wang: Prolonged effects of B-type natriuretic peptide infusion on cardiac remodeling after sustained myocardial injury. in American journal of physiology. Heart and circulatory physiology 2009
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reviews the cardiovascular effects of COX-2 (zeige COX2 Antikörper) inhibitors with a focus on the mechanisms contributing to the clinical readouts of COX-2 (zeige COX2 Antikörper) inhibition.
Colorectal carcinoma harboring ALK (zeige ALK Antikörper) fusions represent a rare aggressive subtype of colorectal carcinoma with distinct clinicopathologic features. This report provides the first clinical evidence that such patients may benefit from targeted monotherapy with ALK (zeige ALK Antikörper) inhibitors.
This finding may provide a new option besides COX (zeige COX8A Antikörper) inhibition to optimize cancer therapy. The outcome of this translational research will guide us to develop a novel omega-6-based diet-care strategy in combination with current chemotherapy for colon cancer prevention and treatment.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (zeige FOSB Antikörper) which, in turn, induces COX-2 (zeige COX2 Antikörper) expression.
A single SNP (rs689466) localized at 5' -1192 of the PTGS2 gene exhibited significant association with febrile seizure (FS) based on case-control allelic association analyses. A significant decrease in the frequency of the G allele in FS was observed compared to that in controls. Using case-control genotypic association analysis, the -1192A allele is most likely to confer susceptibility to FS by a recessive action model.
The anticancer effects by 13'-COOHs appeared to be partially independent of inhibition of COX-2/5-LOX. Using liquid chromatography tandem mass spectrometry, we found that 13'-COOHs increased intracellular dihydrosphingosine and dihydroceramides after short-time incubation in HCT-116 cells, and enhanced ceramides while decreased sphingomyelins during prolonged treatment
Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 (zeige COX2 Antikörper) mediators on human colonic neuromuscular function and epithelial permeability
High PTGS2 expression is associated with metastasis of esophageal squamous cell cancer.
Experimental results indicate that methylmercury inhibits the activity of protein tyrosine phosphatase 1B (zeige PTPN1 Antikörper), which in turn activates the epidermal growth factor receptor (zeige EGFR Antikörper)-p38 mitogen-activated protein kinase (zeige MAPK14 Antikörper) pathway that induces cyclooxygenase-2 expression.
Our data suggest that the molecular network including TSP-1 (zeige THBS1 Antikörper), TGF-beta1 (zeige TGFB1 Antikörper), and PGE2 might be involved in the pathogenesis of acute angle closure glaucoma.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta (zeige IL1B Antikörper),COX-2 (zeige COX2 Antikörper), and TGFbeta1 (zeige TGFB1 Antikörper)
The result demonstrate that mechanical stress on synovial cells induces gene expressions of COX-2 (zeige COX2 Antikörper).
Diabetes enhances the vasodilator response of the rabbit carotid artery to testosterone by a mechanism that includes an increased modulatory activity of the endothelial nitric oxide and an augmented release of COX-2 (zeige COX2 Antikörper) vasodilator, prostacyclin.
Local induction of COX-2 (zeige COX2 Antikörper) during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 (zeige COX2 Antikörper) inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.
These findings suggest that nuclear factor kappa B(NF-kappaB (zeige NFKB1 Antikörper)) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.
COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.
These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.
Brain death increases the expression of COX-1 (zeige COX1 Antikörper) and COX-2 mRNA in the renal medulla
COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.
In porcine vas (zeige AVP Antikörper) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.
expression appears to be positively and negatively regulated by p38 MAPK (zeige MAPK14 Antikörper) and JNK (zeige MAPK8 Antikörper) pathways; alternatively, ERK1/2 (zeige MAPK1/3 Antikörper) appear to be involved in COX-2-independent reparative events that remain to be defined
Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (zeige IL1B Antikörper)-dependent upregulation of COX-2. (Cyclooxygenase 2)
Administration of estrogen early in pregnancy alters endometrial prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA and protein expression, which may disrupt pregnancy causing total embryonic loss during implantation in the pig.
The effect of EGF (zeige EGF Antikörper) on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha (zeige TNF Antikörper)) and cyclooxygenase-2 (COX-2), levels during wound healing in swine is reported.
Cobalt protoporphyrin induces COX-2 (zeige COX2 Antikörper) expression through activating P2X7 (zeige P2RX7 Antikörper) receptors and ASK1 (zeige MAP3K5 Antikörper)/MAP kinases as well as PIAS1 (zeige PIAS1 Antikörper) degradation signaling pathways.
sUV activated the transcription factors nuclear factor-kappaB and activator protein-1 (zeige JUN Antikörper) which, in turn, induces COX-2 (zeige COX2 Antikörper) expression.
Results indicate that Cox-2 (zeige COX2 Antikörper) promotes Col10a1 (zeige COL10A1 Antikörper) expression and chondrocyte hypertrophy in vitro.
These data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS (zeige ROS1 Antikörper) in macrophages.
Our data suggest that there are physiologically important gender differences in hypoxic acclimatization in COX-2 (zeige COX2 Antikörper)-deficient mice. The COX-2 (zeige COX2 Antikörper) signaling pathway appears to be required for acclimatization in oxygen-limiting environments only in males, whereas female COX-2 (zeige COX2 Antikörper)-deficient mice may be able to access COX-2 (zeige COX2 Antikörper)-independent mechanisms to achieve hypoxic acclimatization.
increased COX2 (zeige COX2 Antikörper) expression has an impact on the aging process
These results establish a novel signaling process whereby PAK1 (zeige PAK1 Antikörper) upregulates COX-2 (zeige COX2 Antikörper), reduces anandamide levels and restricts tonic endocannabinoids-mediated processes.
Angiotensin II-AT1-receptor (zeige AGTRAP Antikörper) signaling is necessary for COX-2 (zeige COX2 Antikörper)-dependent normal postnatal nephrogenesis and maturation.
AhR (zeige AHR Antikörper) controls COX-2 (zeige COX2 Antikörper) protein via mRNA stability.
Podocyte-specific knockout of COX2 (zeige COX2 Antikörper) enhanced albuminuria and did not attenuate the histologic features of diabetic kidney disease.
The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.
results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (zeige NR1D1 Antikörper)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2) in both bovine USCs and UECs treated with ovarian steroids
This study showed that neutrophils from periparturient heifers show impairment of COX-2 mRNA expression and lactoferrin (zeige LTF Antikörper), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Antikörper) and PTGS2, and decreased the expression of SOD2 (zeige SOD2 Antikörper), GPX3 (zeige GPX3 Antikörper), DAB2 (zeige DAB2 Antikörper), and NR3C1 (zeige NR3C1 Antikörper). TNF (zeige TNF Antikörper) and IL6 (zeige IL6 Antikörper) levels were also decreased while those of NAMPT (zeige NAMPT Antikörper) were unaffected.
Purinergic P2Y1 receptor (zeige P2RY1 Antikörper) signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts
Data suggest that Escherichia coli infections (here, administration of LPS (zeige IRF6 Antikörper)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 in corpus luteum and has no effect on luteinization in the following cycle.
This study is the first to report the involvement of PGE2 in oocyte MAPK (zeige MAPK1 Antikörper) activation during the maturation process.
Inhibitors of c-Src (zeige SRC Antikörper) (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in oxytocin-induced PGF (zeige PGF Antikörper)(2 alpha) production and reduced COX2 expression by endometrial epithelial cells.
COX-2 pathway is responsible for the endometrial production of PGE (zeige LIPF Antikörper)(2) in the bovine endometrium during the estrous cycle
the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 and GM-CSF (zeige CSF2 Antikörper) during the peri (zeige PLIN1 Antikörper)-attachment period in the cow.
This study showed that COX-1 (zeige PTGS1 Antikörper) and COX-2 in genital carcinomas in the horse is poor; microsomal PGES (zeige PTGES Antikörper)-1 is more prominently expressed.
Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor (zeige OXTR Antikörper), and cyclooxygenase 2 in fetal membranes and endometrium.
COX-1 (zeige PTGS1 Antikörper) and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.
The role for p38 (zeige MAPK14 Antikörper) mitogen-activated kinase (MAPK (zeige MAPK1 Antikörper)) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX (zeige CPOX Antikörper)) gene expression in lipopolysaccharide (LPS (zeige IRF6 Antikörper))-activated equine leukocytes in horses is reported.
In this study, both COX-1 (zeige PTGS1 Antikörper) and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.
Immunoreactivity for COX-1 (zeige PTGS1 Antikörper) and COX-2 is high in equine corneal SCC (zeige CYP11A1 Antikörper), possibly indicating that COX (zeige CPOX Antikörper) plays a role in oncogenesis or progression of this tumor type at this site.
It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.
data support the hypothesis that prostaglandin G/H synthase 2(PGHS2)is a target for the antiluteolytic signal produced by equine conceptuses during early pregnancy
The vesicular gland of castrated goats showed significantly lower AR and COX-2 (zeige COX2 Antikörper) immuno-expression than intact goats indicating that both AR and COX-2 (zeige COX2 Antikörper) are androgen dependent.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
PGH synthase 2
, PHS II
, cyclooxygenase 2b
, prostaglandin G/H synthase 2
, prostaglandin H2 synthase 2
, cyclooxygenase 2
, glucocorticoid-regulated inflammatory cyclooxygenase
, macrophage activation-associated marker protein P71/73
, prostaglandin G/H synthase and cyclooxygenase
, mitogen-inducible PGHS
, cyclooxygenase type 2
, prostaglandin G/H synthase-2
, cyclooxygenase, prostaglandin endoperoxide H synthase-2
, prostaglandin H synthase-2
, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
, prostaglandin G/H synthase 2-like