TEAD1 Antikörper (AA 86-199)

Produktnummer ABIN968251

Produktdetails anti-TEAD1 Antikörper

Target: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Bindungsspezifität: AA 86-199

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TEAD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human TEF-1 aa. 86-199

Klon: 31-TEF

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-TEAD1 Antikörper (ABIN968251)

Ueyama, Zhu, Valenzuela, Suzow, Stewart: "Identification of the functional domain in the transcription factor RTEF-1 that mediates alpha 1-adrenergic signaling in hypertrophied cardiac myocytes." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17476-80, (2000) (PubMed).

Deshpande, Chopra, Rangarajan, Shashidhara, Rodrigues, Krishna: "The human transcription enhancer factor-1, TEF-1, can substitute for Drosophila scalloped during wingblade development." in: The Journal of biological chemistry, Vol. 272, Issue 16, pp. 10664-8, (1997) (PubMed).

Gupta, Amin, Gupta, Hay, Zak: "Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression." in: Molecular and cellular biology, Vol. 17, Issue 7, pp. 3924-36, (1997) (PubMed).

Jacquemin, Hwang, Martial, Dollé, Davidson: "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain." in: The Journal of biological chemistry, Vol. 271, Issue 36, pp. 21775-85, (1996) (PubMed).

Xiao, Davidson, Matthes, Garnier, Chambon: "Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1." in: Cell, Vol. 65, Issue 4, pp. 551-68, (1991) (PubMed).

Details zu TEAD1

Target: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Andere Bezeichnung: TEF-1 (TEAD1 Produkte)

Synonyme: tead1 antikoerper, zgc:63696 antikoerper, TEAD1 antikoerper, xtead1 antikoerper, 2610024B07Rik antikoerper, B230114H05Rik antikoerper, Gtrgeo5 antikoerper, TEAD-1 antikoerper, TEF-1 antikoerper, Tcf13 antikoerper, mTEF-1 antikoerper, AA antikoerper, NTEF-1 antikoerper, REF1 antikoerper, TCF-13 antikoerper, TCF13 antikoerper, XNTEF-1 antikoerper, xlNTEF-1 antikoerper, TEA domain family member 1a antikoerper, TEA domain transcription factor 1 antikoerper, TEA domain family member 1 (SV40 transcriptional enhancer factor) antikoerper, TEA domain family member 1 antikoerper, TEA domain family member 1 (SV40 transcriptional enhancer factor) S homeolog antikoerper, TEA domain family member 1b antikoerper, tead1a antikoerper, TEAD1 antikoerper, tead1 antikoerper, Tead1 antikoerper, tead1.S antikoerper, tead1b antikoerper

Hintergrund: TEF-1 (transcription enhancer factor-1) is a member of a family of transcription factors that contain an evolutionarily conserved DNA binding domain (DBD), TEA/ATTS. TEF-1 was identified as a HeLa cell transcriptional activator that bound, via its TEA domain, to the GT-IIC and Sph enhancer elements. Comparison of various enhancers indicates that TEF-1 binds to highly degenerate DNA sequences and cooperatively interacts with tandem repeats of its binding sites, which increases its enhancer activity. However, the DNA binding activities of TEF-1 are modulated by sequences outside the DBD. The N-terminal basic portion of TEF-1 contains the DBD. The C-terminal portion contains the transactivation domain and a zinc finger-like motif that is thought to be involved in protein dimerization or interaction with additional transcription factors. TEF-1 induced transcription requires a limiting transcriptional intermediary factor (TIF) and a TATA-binding protein associated factor (hTAFIIs). Although TEF-1 is expressed ubiquitously during embryogenesis, its expression is limited to adult kidney, heart, brain, skeletal muscle, and lungs. Disruption of murine TEF-1 gene results in fetal death.

Molekulargewicht: 53 kDa

Pathways: Regulation of Lipid Metabolism by PPARalpha