TEAD1 Antikörper (Internal Region)

Produktnummer ABIN6257778

Produktdetails anti-TEAD1 Antikörper

Target: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TEAD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: TEAD1 Antibody detects endogenous levels of total TEAD1.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TEAD1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl,sodium azide and glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu TEAD1

Target: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Andere Bezeichnung: TEAD1 (TEAD1 Produkte)

Synonyme: tead1 antikoerper, zgc:63696 antikoerper, TEAD1 antikoerper, xtead1 antikoerper, 2610024B07Rik antikoerper, B230114H05Rik antikoerper, Gtrgeo5 antikoerper, TEAD-1 antikoerper, TEF-1 antikoerper, Tcf13 antikoerper, mTEF-1 antikoerper, AA antikoerper, NTEF-1 antikoerper, REF1 antikoerper, TCF-13 antikoerper, TCF13 antikoerper, XNTEF-1 antikoerper, xlNTEF-1 antikoerper, TEA domain family member 1a antikoerper, TEA domain transcription factor 1 antikoerper, TEA domain family member 1 (SV40 transcriptional enhancer factor) antikoerper, TEA domain family member 1 antikoerper, TEA domain family member 1 (SV40 transcriptional enhancer factor) S homeolog antikoerper, TEA domain family member 1b antikoerper, tead1a antikoerper, TEAD1 antikoerper, tead1 antikoerper, Tead1 antikoerper, tead1.S antikoerper, tead1b antikoerper

Hintergrund:

Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Gene: TEAD1

Molekulargewicht: 48 kDa

Gen-ID: 7003

UniProt: P28347

Pathways: Regulation of Lipid Metabolism by PPARalpha