ATG13 Antikörper (Internal Region)
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- Target Alle ATG13 Antikörper anzeigen
- ATG13 (Autophagy Related 13 (ATG13))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ATG13 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- This affinity-purified antibody is directed against human ATG13 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross reactivity with ATG13 from human based on 100% sequence homology with the immunogen. Reactivity against homologues from other sources is not known.
- Produktmerkmale
- ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1 through their stable complex, and the regulation of ATG13-ULK1-RB1CC1. ATG13 also forms a stable complex with FIP200. Ulk1 phosphorylates ATG13 on S318 and promotes its release to damaged mitochondria. Autophagy is a normal process in eukaryotes required for turnover of cellular components during starvation and stress. It plays an essential role in cellular differentiation, cell death and aging. Defects in this evolutionarily conserved process may contribute to certain human diseases such as cancer, neurodegenerative diseases, muscular disorders and pathogen infections. ATG13 is one of several ATG genes required for autophagosome formation in mammalian cells. mTOR interacts with this complex in a nutrient dependent manner and phosphorylates Atg13 and ULK1.
- Aufreinigung
- affinity purified
- Sterilität
- Sterile filtered
- Immunogen
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This affinity purified antibody was prepared by repeated immunizations with a synthetic peptide corresponding to the S318 region of ATG13.
Immunogen Type: Peptide - Isotyp
- IgG
- Top Product
- Discover our top product ATG13 Primärantikörper
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- Applikationshinweise
- This affinity purified antibody has been tested for use in ELISA and by western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 56.6 kDa in size corresponding to human ATG13 protein by western blotting in the appropriate stimulated tissue or cell lysate or extract.
- Kommentare
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Gene Name: ATG13
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1.24 mg/mL
- Buffer
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
- Haltbarkeit
- 12 months
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Autophagy control by the VEGF-C/NRP-2 axis in cancer and its implication for treatment resistance." in: Cancer research, Vol. 73, Issue 1, pp. 160-71, (2013) (PubMed).
: "mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6." in: Nature cell biology, Vol. 15, Issue 4, pp. 406-16, (2013) (PubMed).
: "Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy." in: Molecular cell, Vol. 43, Issue 4, pp. 572-85, (2011) (PubMed).
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Autophagy control by the VEGF-C/NRP-2 axis in cancer and its implication for treatment resistance." in: Cancer research, Vol. 73, Issue 1, pp. 160-71, (2013) (PubMed).
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- Target
- ATG13 (Autophagy Related 13 (ATG13))
- Andere Bezeichnung
- ATG13 (ATG13 Produkte)
- Synonyme
- zgc:63526 antikoerper, KIAA0652 antikoerper, PARATARG8 antikoerper, 1110053A20Rik antikoerper, D2Ertd391e antikoerper, Harbi1 antikoerper, Harbi1l antikoerper, RGD1310685 antikoerper, autophagy related 13 antikoerper, ATG13 autophagy related 13 homolog (S. cerevisiae) antikoerper, ATG13 antikoerper, atg13 antikoerper, Atg13 antikoerper
- Hintergrund
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ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1 through their stable complex, and the regulation of ATG13-ULK1-RB1CC1. ATG13 also forms a stable complex with FIP200. Ulk1 phosphorylates ATG13 on S318 and promotes its release to damaged mitochondria. Autophagy is a normal process in eukaryotes required for turnover of cellular components during starvation and stress. It plays an essential role in cellular differentiation, cell death and aging. Defects in this evolutionarily conserved process may contribute to certain human diseases such as cancer, neurodegenerative diseases, muscular disorders and pathogen infections. ATG13 is one of several ATG genes required for autophagosome formation in mammalian cells. mTOR interacts with this complex in a nutrient dependent manner and phosphorylates Atg13 and ULK1.
Synonyms: Autophagy-related protein 13, KIAA0652 - Gen-ID
- 9776
- NCBI Accession
- NP_001136145
- UniProt
- O75143
- Pathways
- PI3K-Akt Signalweg, Autophagie
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