SETD2 Antikörper (Internal Region)

Produktnummer ABIN954755

Produktdetails anti-SETD2 Antikörper

Target: SETD2 (SET Domain Containing 2 (SETD2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SETD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-ERDPDKQTQN KE

Spezifität: This antibody recognizes HYPB / SETD2 (internal region).

Kreuzreaktivität (Details): Species reactivity (expected):Human.
Species reactivity (tested):Mouse.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_054878.3. Genename: SETD2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SETD2

Target: SETD2 (SET Domain Containing 2 (SETD2))

Andere Bezeichnung: SETD2 / HIF1 (SETD2 Produkte)

Synonyme: Kif9 antikoerper, HBP231 antikoerper, HIF-1 antikoerper, HIP-1 antikoerper, HYPB antikoerper, KMT3A antikoerper, SET2 antikoerper, p231HBP antikoerper, SET domain containing 2 antikoerper, Setd2 antikoerper, SETD2 antikoerper

Hintergrund: SET2 is a Histone methyltransferase that methylates 'Lys-36' of Histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. This protein probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. SET2 binds DNA at promoters, and may act as a transcription activator. SET2 binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SET2 belongs to a class of huntingtin interacting proteins characterized by WW motifs.Synonyms: HIF-1, HIP-1, HIP1, HYPB, Histone-lysine N-methyltransferase SETD2, Huntingtin yeast partner B, Huntingtin-interacting protein 1, Huntingtin-interacting protein B, KIAA1732, KMT3A, Lysine N-methyltransferase 3A, SET domain-containing protein 2, SET2, p231HBP

Gen-ID: 29072

NCBI Accession: NP_054878

Pathways: Tube Formation