DFFA Antikörper (C-Term)

Produktnummer ABIN951895

Produktdetails anti-DFFA Antikörper

Target: DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Bindungsspezifität: AA 302-331, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DFFA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes Human DFFA / ICAD (C-term).

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 302~331 amino acids from the C-terminal region of Human DFFA / ICAD. Genename: DFFA

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu DFFA

Target: DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Andere Bezeichnung: DFFA / ICAD (DFFA Produkte)

Synonyme: DFF-45 antikoerper, DFF1 antikoerper, ICAD antikoerper, A330085O09Rik antikoerper, DFF35 antikoerper, Dff45 antikoerper, ICAD-L antikoerper, ICAD-S antikoerper, DFFA antikoerper, zgc:92229 antikoerper, DNA fragmentation factor subunit alpha antikoerper, DNA fragmentation factor, alpha subunit antikoerper, DNA fragmentation factor, 45kDa, alpha polypeptide antikoerper, DNA fragmentation factor, alpha polypeptide antikoerper, DFFA antikoerper, Dffa antikoerper, dffa antikoerper

Hintergrund: DFFA is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.Synonyms: DFF-45, DFF1, DFF45, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, Inhibitor of CAD

Molekulargewicht: 36522 Da

Gen-ID: 1676

NCBI Accession: NP_004392

Pathways: Apoptose, Caspase Kaskade in der Apoptose