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DFFA Produkte

(DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Kategorien

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Ausgewählte DFFA Kategorien

DFFA Antikörper

High quality antibodies with extensive validation data.

DFFA ELISA Kits

Reliable ELISA kits for a wide range of species.

DFFA Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene DFFA Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC, IP
Validierungen
  • (4)
Kat. Nr. ABIN7150176
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, ICC
Validierungen
  • (4)
Kat. Nr. ABIN7442849
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, FACS
Validierungen
  • (4)
Kat. Nr. ABIN7193432
Menge 0.1 mg
Datenblatt Datenblatt

Empfohlene DFFA ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN4882605
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6384470
Menge 96 tests
Datenblatt Datenblatt

Empfohlene DFFA Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7122682
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3131753
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3078953
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren DFFA Produkten

Fulda, Meyer, Debatin: "Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression." in: Oncogene, Vol. 21, Issue 15, pp. 2283-94, (2002) (PubMed).

Li, Chen, Sinogeeva, Gorospe, Wersto, Chrest, Barnes, Liu: "Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49504-10, (2002) (PubMed).

Fukushima, Kikuchi, Koshiba, Kigawa, Kuroda, Yokoyama: "Solution structure of the DFF-C domain of DFF45/ICAD. A structural basis for the regulation of apoptotic DNA fragmentation." in: Journal of molecular biology, Vol. 321, Issue 2, pp. 317-27, (2002) (PubMed).

Charrier, Jarry, Toquet, Bou-Hanna, Chedorge, Denis, Vallette, Laboisse: "Growth phase-dependent expression of ICAD-L/DFF45 modulates the pattern of apoptosis in human colonic cancer cells." in: Cancer research, Vol. 62, Issue 7, pp. 2169-74, (2002) (PubMed).

Nagata, Kishi, Liu, Matsuda, Imanaka, Tsukada, Kang, Muraguchi: "The regulation of DNAse activities in subcellular compartments of activated thymocytes." in: Immunology, Vol. 105, Issue 4, pp. 399-406, (2002) (PubMed).

Boulares, Zoltoski, Yakovlev, Xu, Smulson: "Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 41, pp. 38185-92, (2001) (PubMed).

Sakahira, Enari, Nagata: "Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L, and ICAD-S." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15740-4, (1999) (PubMed).

Gu, Dong, Zhang, McLaughlin, Wu, Schlossman: "Functional interaction of DFF35 and DFF45 with caspase-activated DNA fragmentation nuclease DFF40." in: The Journal of biological chemistry, Vol. 274, Issue 30, pp. 20759-62, (1999) (PubMed).

Enari, Sakahira, Yokoyama, Okawa, Iwamatsu, Nagata: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, (1998) (PubMed).

Sakahira, Enari, Nagata: "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis." in: Nature, Vol. 391, Issue 6662, pp. 96-9, (1998) (PubMed).

Synonyme und alternative Namen zu DFFA

DNA fragmentation factor subunit alpha (DFFA), DNA fragmentation factor, alpha subunit (Dffa), DNA fragmentation factor, 45kDa, alpha polypeptide (dffa), DNA fragmentation factor subunit alpha (Dffa), DNA fragmentation factor, alpha polypeptide (dffa), A330085O09Rik, DFF-45, DFF1, DFF35, Dff45, DFFA, ICAD, ICAD-L, ICAD-S, zgc:92229

Bezeichner auf Proteinebene für DFFA

  • DFF45
  • DNA fragmentation factor 45 kDa subunit
  • DNA fragmentation factor subunit alpha
  • inhibitor of CAD
  • DFF-45
  • DNA fragmentation factor, 45kDa, alpha polypeptide
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