SHC1 Antikörper (C-Term)

Produktnummer ABIN928366

Produktdetails anti-SHC1 Antikörper

Target: SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Huhn, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus, Ratte (Rattus), Rind (Kuh), Frosch, Huhn, Hund, Zebrafisch (Brachydanio rerio)

Aufreinigung: Purified

Immunogen: SHC1 antibody was raised in rabbit using the C terminal of SHC1 as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

SHC1 Blocking Peptide, catalog no. 33R-1145, is also available for use as a blocking control in assays to test for specificity of this SHC1 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu SHC1

Target: SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))

Andere Bezeichnung: SHC1 (SHC1 Produkte)

Synonyme: SHC1 antikoerper, SHC antikoerper, SHCA antikoerper, P66shc antikoerper, si:dkey-246i14.4 antikoerper, wu:fc10h03 antikoerper, shc antikoerper, p66shc antikoerper, Shc antikoerper, ShcA antikoerper, p66 antikoerper, SHC adaptor protein 1 antikoerper, Shc1p antikoerper, squalene--hopene cyclase antikoerper, SHC (Src homology 2 domain containing) transforming protein 1 antikoerper, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog antikoerper, src homology 2 domain-containing transforming protein C1 antikoerper, SHC1 antikoerper, shc1 antikoerper, Shc1 antikoerper, shc1.L antikoerper

Hintergrund: SHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. Synonyms: Polyclonal SHC1 antibody, Anti-SHC1 antibody, SHC, Src homology 2 domain containing transforming protein 1 antibody, FLJ26504 antibody, SHC antibody, SHCA antibody, p52SHC antibody, p66 antibody, p66SHC antibody.

Pathways: RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2