TIRAP Antikörper (Internal Region)

Produktnummer ABIN920633

Produktdetails anti-TIRAP Antikörper

Target: TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIRAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Positive Control: Found in the cytoplasm and highly expressed in the liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon, and brain.

Aufreinigung: Antigen Immunoaffinity purified

Immunogen: Rabbit polyclonal TIRAP antibody was raised against a peptide corresponding to amino acids near the middle of human TIRAP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: use at 4 µg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu TIRAP

Target: TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Andere Bezeichnung: Toll Interleukin 1 Receptor Adaptor Protein (TIRAP) (TIRAP Produkte)

Synonyme: mal antikoerper, wyatt antikoerper, BACTS1 antikoerper, Mal antikoerper, MyD88-2 antikoerper, AA407980 antikoerper, C130027E04Rik antikoerper, Tlr4ap antikoerper, Wyatt antikoerper, toll-interleukin 1 receptor (TIR) domain containing adaptor protein antikoerper, TIR domain containing adaptor protein antikoerper, toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog antikoerper, toll-interleukin 1 receptor (TIR) domain-containing adaptor protein antikoerper, tirap antikoerper, TIRAP antikoerper, tirap.L antikoerper, Tirap antikoerper

Hintergrund: Toll-like receptors (TRLs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. In TIRAP deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-B and MAP kinase activation, suggesting that TIRAP is also involved in TLR4 signaling. Synonyms:

Molekulargewicht: 26 kDa

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades