WASF1 Antikörper (AA 481-559) (Alexa Fluor 647)

Produktnummer ABIN919892

Produktdetails anti-WASF1 Antikörper (Alexa Fluor 647)

Target: WASF1 (WAS Protein Family, Member 1 (WASF1))

Bindungsspezifität: AA 481-559

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WASF1 Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human WAVE 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu WASF1

Target: WASF1 (WAS Protein Family, Member 1 (WASF1))

Andere Bezeichnung: WAVE 1 (WASF1 Produkte)

Synonyme: scar1 antikoerper, wave1 antikoerper, ATRANGAP2 antikoerper, ATSCAR1 antikoerper, SCAR1 antikoerper, T14G11.27 antikoerper, T14G11_27 antikoerper, WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY VERPROLIN HOMOLOGOUS PROTEIN 1 antikoerper, wave antikoerper, WAVE antikoerper, WAVE1 antikoerper, AI195380 antikoerper, AI838537 antikoerper, Scar antikoerper, WAVE-1 antikoerper, WAS protein family member 1 S homeolog antikoerper, SCAR family protein antikoerper, WAS protein family member 1 antikoerper, WAS protein family, member 1 antikoerper, wasf1.S antikoerper, AT2G34150 antikoerper, wasf1 antikoerper, WASF1 antikoerper, Wasf1 antikoerper

Hintergrund:

Synonyms: Protein WAVE-1, Protein WAVE1, SCAR1, Similar to a plant extensin like protein, Verprolin homology domain containing protein 1, Verprolin homology domain-containing protein 1, WAS protein family, member 1, Wasf1, WASF1_HUMAN, WASL, WASP family 1, WASP family protein member 1, WAVE, WAVE1, Wiskott Aldrich syndrome protein family member 1, Wiskott-Aldrich syndrome protein family member 1.

Background: WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in Actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the Actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating Actin reorganization downstream of the Rho family of small GTPases. The protein homologs WAVE1 and WAVE2 regulate membrane ruffling by inducing the formation of Actin filament clusters in response to GTP binding and by activating Rac. They mediate Actin polymerization by cooperating with the Arp2/3 complex, thereby promoting the formation of Actin filaments. WAVE1, which is also designated SCAR (suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed, with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases with Actin and plays a role in the transduction of signals involving changes in cell shape, function or motility.

Gen-ID: 8936

Pathways: RTK Signalweg, Regulation of Actin Filament Polymerization