KDM5B Antikörper (AA 65-165) (Alexa Fluor 555)

Produktnummer ABIN903570

Produktdetails anti-KDM5B Antikörper (Alexa Fluor 555)

Target: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Bindungsspezifität: AA 65-165

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM5B Antikörper ist konjugiert mit Alexa Fluor 555

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Pig,Horse,Chicken,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KDM5B/Jarid1B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu KDM5B

Target: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Andere Bezeichnung: KDM5B (KDM5B Produkte)

Synonyme: jarid1b antikoerper, jarid1ba antikoerper, id:ibd5050 antikoerper, wu:fd15c05 antikoerper, cb264 antikoerper, jarid1bb antikoerper, plu1 antikoerper, wu:fc44h11 antikoerper, zgc:85741 antikoerper, JARID1B antikoerper, CT31 antikoerper, PLU-1 antikoerper, PLU1 antikoerper, PUT1 antikoerper, RBBP2H1A antikoerper, 2010009J12Rik antikoerper, 2210016I17Rik antikoerper, AW556288 antikoerper, D1Ertd202e antikoerper, Jarid1b antikoerper, Plu1 antikoerper, Rb-Bp2 antikoerper, mKIAA4034 antikoerper, RGD1565602 antikoerper, lysine (K)-specific demethylase 5Ba antikoerper, lysine (K)-specific demethylase 5Bb antikoerper, lysine demethylase 5B antikoerper, lysine (K)-specific demethylase 5B antikoerper, kdm5ba antikoerper, kdm5bb antikoerper, KDM5B antikoerper, Kdm5b antikoerper

Hintergrund:

Synonyms: CT31, PLU1, PUT1, PLU-1, JARID1B, PPP1R98, RBBP2H1A, Lysine-specific demethylase 5B, Cancer/testis antigen 31, Histone demethylase JARID1B, Jumonji/ARID domain-containing protein 1B, Retinoblastoma-binding protein 2 homolog 1, RBP2-H1, KDM5B, RBBP2H1

Background: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

Gen-ID: 10765

UniProt: Q9UGL1

Pathways: Warburg Effekt