DICER1 Antikörper (AA 1301-1400) (Alexa Fluor 350)

Produktnummer ABIN893989

Produktdetails anti-DICER1 Antikörper (Alexa Fluor 350)

Target: DICER1 (Dicer 1, Ribonuclease Type III (DICER1))

Bindungsspezifität: AA 1301-1400

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DICER1 Antikörper ist konjugiert mit Alexa Fluor 350

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DICER1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu DICER1

Target: DICER1 (Dicer 1, Ribonuclease Type III (DICER1))

Andere Bezeichnung: DICER1 (DICER1 Produkte)

Synonyme: dcr1 antikoerper, dicer antikoerper, herna antikoerper, DICER1 antikoerper, dicer1 antikoerper, 1110006F08Rik antikoerper, D12Ertd7e antikoerper, mKIAA0928 antikoerper, DCR1 antikoerper, Dicer antikoerper, HERNA antikoerper, MNG1 antikoerper, DICER antikoerper, fc39d11 antikoerper, fc74b05 antikoerper, wu:fc39d11 antikoerper, wu:fc74b05 antikoerper, dicer 1, ribonuclease III antikoerper, endoribonuclease Dicer antikoerper, dicer 1, ribonuclease III S homeolog antikoerper, dicer 1, ribonuclease type III antikoerper, dicer 1 ribonuclease III antikoerper, DICER1 antikoerper, CpipJ_CPIJ010534 antikoerper, dicer1 antikoerper, dicer1.S antikoerper, Dicer1 antikoerper

Hintergrund:

Synonyms: DCR1, MNG1, Dicer, HERNA, RMSE2, Dicer1e, K12H4.8-LIKE, Endoribonuclease Dicer, Helicase with RNase motif, Helicase MOI, DICER1, KIAA0928

Background: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

Gen-ID: 23405

UniProt: Q9UPY3

Pathways: Regulatorische RNA Pathways, Stem Cell Maintenance, Ribonucleoprotein Complex Subunit Organization