ATG7 Antikörper (AA 21-120) (Alexa Fluor 647)

Produktnummer ABIN883014

Produktdetails anti-ATG7 Antikörper (Alexa Fluor 647)

Target: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Bindungsspezifität: AA 21-120

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG7 Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ATG7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ATG7

Target: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Andere Bezeichnung: Apg7 (ATG7 Produkte)

Synonyme: APG7-LIKE antikoerper, APG7L antikoerper, GSA7 antikoerper, D8 antikoerper, UBA1B antikoerper, UBE1L antikoerper, UBE2 antikoerper, Ube1l antikoerper, 1300004C08Rik antikoerper, AO090001000744 antikoerper, atg7 antikoerper, 1810013K23Rik antikoerper, Agp7 antikoerper, Apg7l antikoerper, Atg7l antikoerper, ATAPG7 antikoerper, ATATG7 antikoerper, ATG7 antikoerper, AUTOPHAGY 7 antikoerper, AUTOPHAGY-RELATED 7 antikoerper, K15I22.10 antikoerper, K15I22_10 antikoerper, autophagy related 7 antikoerper, ubiquitin like modifier activating enzyme 7 antikoerper, ubiquitin-like modifier activating enzyme 7 antikoerper, autophagy-related protein 7 antikoerper, Autophagy-related protein 7 antikoerper, Apg7p antikoerper, ThiF family protein antikoerper, ubiquitin-like conjugating enzyme Atg7 antikoerper, ATG7 antikoerper, UBA7 antikoerper, Uba7 antikoerper, ANI_1_3368024 antikoerper, AOR_1_1338164 antikoerper, PTRG_02236 antikoerper, PAAG_00287 antikoerper, PITG_12537 antikoerper, atg7 antikoerper, Atg7 antikoerper, APG7 antikoerper

Hintergrund:

Synonyms: GSA7, APG7L, APG7-LIKE, Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, hAGP7, Ubiquitin-activating enzyme E1-like protein, ATG7

Background: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

Gen-ID: 10533

UniProt: O95352

Pathways: Response to Water Deprivation, Autophagie