STAM Antikörper (AA 101-200)

Produktnummer ABIN873004

Produktdetails anti-STAM Antikörper

Target: STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))

Bindungsspezifität: AA 101-200

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAM Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human STAM

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu STAM

Target: STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))

Andere Bezeichnung: STAM (STAM Produkte)

Synonyme: STAM-1 antikoerper, STAM1 antikoerper, wu:fv75b10 antikoerper, zgc:55725 antikoerper, RGD1564499 antikoerper, signal transducing adaptor molecule antikoerper, signal transducing adapter molecule 1 antikoerper, Signal transducing adapter molecule 1 antikoerper, signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antikoerper, STAM antikoerper, CpipJ_CPIJ003516 antikoerper, Tsp_03939 antikoerper, stam-1 antikoerper, Stam antikoerper, stam antikoerper

Hintergrund:

Synonyms: Signal transducing adapter molecule 1, Signal transducing adapter molecule 2, Signal transducing adaptor molecule SH3 domain and ITAM mot 1, Signal transducing adaptor molecule, STAM 1, STAM-2, STAM1, Stam2, STAM2_HUMAN, DKFZp686J2352, Hrs-binding protein, HSE1 homolog, OTTHUMP00000019237.

Background: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Gen-ID: 8027

Pathways: EGFR Signaling Pathway, EGFR Downregulation