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STAM Antikörper (Center)

STAM Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2856220
  • Target Alle STAM Antikörper anzeigen
    STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))
    Bindungsspezifität
    • 9
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reaktivität
    • 48
    • 19
    • 9
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 45
    • 5
    • 1
    • 1
    Kaninchen
    Klonalität
    • 49
    • 3
    Polyklonal
    Konjugat
    • 35
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser STAM Antikörper ist unkonjugiert
    Applikation
    • 39
    • 22
    • 21
    • 9
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Maus, Xenopus laevis, Rind (Kuh), Xenopus tropicalis
    Kreuzreaktivität (Details)
    Mouse (96 %), Xenopus laevis (88 %), Bovine (97 %), Xenopus tropicalis (90 %)
    Produktmerkmale
    Rabbit Polyclonal antibody to STAM (signal transducing adaptor molecule (SH3 domain and ITAM motif) 1)
    STAM antibody
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human STAM. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product STAM Primärantikörper
  • Applikationshinweise
    Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
    Kommentare

    Positive Control: 293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))
    Andere Bezeichnung
    STAM (STAM Produkte)
    Synonyme
    STAM-1 antikoerper, STAM1 antikoerper, wu:fv75b10 antikoerper, zgc:55725 antikoerper, RGD1564499 antikoerper, signal transducing adaptor molecule antikoerper, signal transducing adapter molecule 1 antikoerper, Signal transducing adapter molecule 1 antikoerper, signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antikoerper, STAM antikoerper, CpipJ_CPIJ003516 antikoerper, Tsp_03939 antikoerper, stam-1 antikoerper, Stam antikoerper, stam antikoerper
    Hintergrund
    This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte grwoth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.

    Cellular Localization: Cytoplasm (Probable) , Early endosome membrane, Peripheral membrane protein, Cytoplasmic side
    Molekulargewicht
    59 kDa
    Gen-ID
    8027
    Pathways
    EGFR Signaling Pathway, EGFR Downregulation
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