STAM Antikörper (N-Term)

Produktnummer ABIN1882134

Produktdetails anti-STAM Antikörper

Target: STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))

Bindungsspezifität: AA 1-30, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This STAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human STAM.

Klon: RB4633

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-STAM Antikörper (ABIN1882134)

Ortiz, Lee, Smith, Forman, Lee, Liu: "Comparative analyses of differentially induced T-cell receptor-mediated phosphorylation pathways in T lymphoma cells." in: Experimental biology and medicine (Maywood, N.J.), Vol. 235, Issue 12, pp. 1450-63, (2010) (PubMed).

Details zu STAM

Target: STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))

Andere Bezeichnung: STAM (STAM Produkte)

Synonyme: STAM-1 antikoerper, STAM1 antikoerper, wu:fv75b10 antikoerper, zgc:55725 antikoerper, RGD1564499 antikoerper, signal transducing adaptor molecule antikoerper, signal transducing adapter molecule 1 antikoerper, Signal transducing adapter molecule 1 antikoerper, signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antikoerper, STAM antikoerper, CpipJ_CPIJ003516 antikoerper, Tsp_03939 antikoerper, stam-1 antikoerper, Stam antikoerper, stam antikoerper

Hintergrund: Stimulation of cells with cytokines initiates a signal transduction cascade involving cytokine receptors, Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). STAM for 'signal-transducing adaptor molecule, induced after stimulation of cells with cytokine IL2, is a component of signal transduction downstream of JAK3.1 Human STAM cDNA cloned from a T-cell cDNA library encodes a 540-amino acid protein precipitated by anti-phosphotyrosine. Northern blot analysis indicates that STAM is expressed as a 2.9-kb message in a wide variety of tissue and cell types. The STAM sequence contains a Src-homology 3 (SH3) domain and an immunoreceptor tyrosine-based activation motif (ITAM). It has been suggested that STAM acts as an adaptor molecule in signal transduction pathways from cytokine receptors.

Molekulargewicht: 59180

NCBI Accession: NP_003464

UniProt: Q92783

Pathways: EGFR Signaling Pathway, EGFR Downregulation