RPS6KA2 Antikörper (pThr353, pThr356)

Produktnummer ABIN745238

Produktdetails anti-RPS6KA2 Antikörper

Target: RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))

Bindungsspezifität: pThr353, pThr356

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPS6KA2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human RSK3 around the phosphorylation site of Thr353/356

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu RPS6KA2

Target: RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))

Andere Bezeichnung: RSK3 + (RPS6KA2 Produkte)

Synonyme: HU-2 antikoerper, MAPKAPK1C antikoerper, RSK antikoerper, RSK3 antikoerper, S6K-alpha antikoerper, S6K-alpha2 antikoerper, p90-RSK3 antikoerper, pp90RSK3 antikoerper, 90kDa antikoerper, D17Wsu134e antikoerper, Rps6ka-rs1 antikoerper, Rsk3 antikoerper, p90rsk antikoerper, pp90rsk antikoerper, ribosomal protein S6 kinase A2 antikoerper, ribosomal protein S6 kinase, polypeptide 2 antikoerper, Rps6ka2 antikoerper, RPS6KA2 antikoerper

Hintergrund:

Synonyms: 90 kDa ribosomal protein S6 kinase 2, HU 2, KS6A2_HUMAN, MAP kinase activated protein kinase 1c, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, MAPKAPK1C, p90-RSK 2, p90RSK 2, p90RSK2, pp90RSK 3, pp90RSK3, Ribosomal protein S6 kinase alpha-2, Ribosomal S6 kinase 3, RPS6KA2, RSK 3, RSK-3, S6K alpha 2, S6K alpha, S6K-alpha-2.

Background: RSK3(Ribosomal S6 kinase 3)is a member of a family of 90- kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases that are activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2. Rsk3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, phosphorylates potential nuclear targets and may have a unique upstream activator. Several sites, such as Ser380, Thr359, Ser363 and Thr573, are important for its activation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.

Gen-ID: 6196

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung, Regulation of Systemic Arterial Blood Pressure by Hormones, Activation of Innate immune Response, Toll-Like Receptors Cascades