Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 140-190) Antikörper (FITC)

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Antigen
  • RAGE
  • AGER
  • advanced glycosylation end-product specific receptor
  • advanced glycosylation end product-specific receptor
  • MAPK/MAK/MRK overlapping kinase
  • AGER
  • Ager
  • LOC719012
Epitop
AA 140-190
61
31
15
14
13
10
8
7
7
6
6
5
5
5
5
5
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Ratte (Rattus)
244
125
74
7
5
4
3
3
3
3
1
1
Wirt
Kaninchen
249
33
16
14
2
Klonalität
Polyklonal
Konjugat
FITC
19
16
15
9
8
8
5
5
4
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
216
132
129
76
45
25
21
13
12
6
4
4
1
1
1
Optionen
Hersteller
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Immunogen KLH conjugated synthetic peptide derived from rat AGER
Isotyp IgG
Reinigung Purified by Protein A.
Andere Bezeichnung RAGE (AGER Antibody Abstract)
Hintergrund

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

Subcellular location: Extracellular

Synonyms: RAGE, Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, Ager

Gen-ID 81722
UniProt Q63495
Pathways Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration
Applikationshinweise FCM 1:20-100
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
Produkt verwendet in: Zhu, Yao, Zhang, Dong, Yu, Sheng: "Anti-RAGE antibody ameliorates severe thermal injury in rats through regulating cellular immune function." in: Acta pharmacologica Sinica, Vol. 35, Issue 9, pp. 1167-76, 2014 (PubMed). (Probematerial (Species): Rat (Rattus)).

Braach, Buschmann, Pflaum, Hudalla, Koch, Ryschich, Poeschl, Frommhold: "Anti-inflammatory functions of protein C require RAGE and ICAM-1 in a stimulus-dependent manner." in: Mediators of inflammation, Vol. 2014, pp. 743678, 2014 (PubMed).

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