RAGE Antikörper (AA 151-250)

Produktnummer ABIN725900

Es sind 5+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-RAGE Antikörper wird verwendet zum Nachweis von RAGE in Proben von Ratte. Er wurde validiert für WB, IP, IHC (p), IF (cc), IF (p) und IHC (fro).

Kurzübersicht für RAGE Antikörper (AA 151-250) (ABIN725900)

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAGE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-RAGE Antikörper

Bindungsspezifität: AA 151-250

Verwendungszweck: RAGE Polyclonal Antibody

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat AGER

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000),

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-RAGE Antikörper (ABIN725900)

Fu, Shi, Song, Liu, Wang, Wang, Song, Song: "From the Cover: Tetrachlorobenzoquinone Exerts Neurological Proinflammatory Activity by Promoting HMGB1 Release, Which Induces TLR4 Clustering within the Lipid Raft." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 153, Issue 2, pp. 303-15, (2016) (PubMed).

Sun, Liu, Xue, Wang: "Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats." in: Journal of neuroscience research, Vol. 93, Issue 4, pp. 666-77, (2015) (PubMed).

Zhu, Yao, Zhang, Dong, Yu, Sheng: "Anti-RAGE antibody ameliorates severe thermal injury in rats through regulating cellular immune function." in: Acta pharmacologica Sinica, Vol. 35, Issue 9, pp. 1167-76, (2014) (PubMed).

Yu, Wu, Cai, Xiang, Zha, Fan, Guo, Ming, Liu: "Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats." in: PLoS ONE, Vol. 7, Issue 12, pp. e52013, (2012) (PubMed).

Huang, Yao, Zhang, Dong, Yu, Sheng: "The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats." in: Shock (Augusta, Ga.), Vol. 31, Issue 3, pp. 322-9, (2009) (PubMed).

Details zu RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Andere Bezeichnung: RAGE

Hintergrund:

Synonyms: RAGE, Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, Ager

Background: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

Gen-ID: 81722

UniProt: Q63495

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteine