ASAP2 Antikörper (N-Term)
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- Target Alle ASAP2 Antikörper anzeigen
- ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ASAP2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Kreuzreaktivität
- Human, Maus
- Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the N-terminus region of human PAG3. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product ASAP2 Primärantikörper
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- Applikationshinweise
- WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Kommentare
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Positive Control: Mouse brain , A431 , Raji
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.77 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
- Konservierungsmittel
- Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))
- Andere Bezeichnung
- ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2 Produkte)
- Synonyme
- DDEF2 antikoerper, ddef2 antikoerper, asap2 antikoerper, si:dkey-37o8.2 antikoerper, AMAP2 antikoerper, CENTB3 antikoerper, PAG3 antikoerper, PAP antikoerper, Pap-alpha antikoerper, SHAG1 antikoerper, 6530401G17Rik antikoerper, Ddef2 antikoerper, Gm1523 antikoerper, Gm592 antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 L homeolog antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b antikoerper, ASAP2 antikoerper, asap2.L antikoerper, asap1b antikoerper, asap2 antikoerper, Asap2 antikoerper
- Hintergrund
- ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 , AMAP2 , CENTB3 , DDEF2 , PAG3 , PAP , Pap-alpha , SHAG1,This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Molekulargewicht
- 112 kDa
- Gen-ID
- 8853
- UniProt
- O43150
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