ASAP2 Antikörper (AA 1-120)

Produktnummer ABIN7265659

Produktdetails anti-ASAP2 Antikörper

Target: ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))

Bindungsspezifität: AA 1-120

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: ASAP2 Rabbit pAb

Sequenz: MPDQISVSEF VAETHEDYKA PTASSFTTRT AQCRNTVAAI EEALDVDRMV LYKMKKSVKA INSSGLAHVE NEEQYTQALE KFGGNCVCRD DPDLGSAFLK FSVFTKELTA LFKNLIQNMN

Kreuzreaktivität: Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human ASAP2 (NP_001128663).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ASAP2

Target: ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))

Andere Bezeichnung: ASAP2 (ASAP2 Produkte)

Synonyme: DDEF2 antikoerper, ddef2 antikoerper, asap2 antikoerper, si:dkey-37o8.2 antikoerper, AMAP2 antikoerper, CENTB3 antikoerper, PAG3 antikoerper, PAP antikoerper, Pap-alpha antikoerper, SHAG1 antikoerper, 6530401G17Rik antikoerper, Ddef2 antikoerper, Gm1523 antikoerper, Gm592 antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 L homeolog antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b antikoerper, ASAP2 antikoerper, asap2.L antikoerper, asap1b antikoerper, asap2 antikoerper, Asap2 antikoerper

Hintergrund: This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008],AMAP2,CENTB3,DDEF2,PAG3,PAP,Pap-alpha,SHAG1,ASAP2,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,ASAP2

Gen-ID: 8853

UniProt: O43150