LAMTOR1 Antikörper (AA 111-161)

Produktnummer ABIN7452946

Produktdetails anti-LAMTOR1 Antikörper

Target: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Bindungsspezifität: AA 111-161

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAMTOR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit anti-LAMTOR1 Antibody, Affinity Purified

Homologie: Mouse,Rat,Bovine,Orangutan

Aufreinigung: Affinity Purified

Immunogen: Between AA 111 and 161

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: Not recommended

WB: 1:1,000 - 1:5,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu LAMTOR1

Target: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Andere Bezeichnung: LAMTOR1 (LAMTOR1 Produkte)

Synonyme: C11orf59 antikoerper, PDRO antikoerper, Ragulator1 antikoerper, p18 antikoerper, p27RF-Rho antikoerper, 2400001E08Rik antikoerper, Pdro antikoerper, C15H11orf59 antikoerper, c11orf59 antikoerper, flj20625 antikoerper, p27rf-rho antikoerper, pdro antikoerper, ragulator1 antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 S homeolog antikoerper, LAMTOR1 antikoerper, Lamtor1 antikoerper, lamtor1.S antikoerper

Hintergrund: Background: As part of the Ragulator complex, LAMTOR1 is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. LAMTOR1 is activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. It is also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. It may also play a role in RHOA activation [taken from the Universal Protein Resource (UniProt) Q6IAA8].

Gen-ID: 55004

UniProt: Q6IAA8