LAMTOR1 Antikörper (AA 2-161) (HRP)

Produktnummer ABIN7167071

Produktdetails anti-LAMTOR1 Antikörper (HRP)

Target: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Bindungsspezifität: AA 2-161

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAMTOR1 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Ragulator complex protein LAMTOR1 protein (2-161AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu LAMTOR1

Target: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Andere Bezeichnung: LAMTOR1 (LAMTOR1 Produkte)

Synonyme: C11orf59 antikoerper, PDRO antikoerper, Ragulator1 antikoerper, p18 antikoerper, p27RF-Rho antikoerper, 2400001E08Rik antikoerper, Pdro antikoerper, C15H11orf59 antikoerper, c11orf59 antikoerper, flj20625 antikoerper, p27rf-rho antikoerper, pdro antikoerper, ragulator1 antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 antikoerper, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 S homeolog antikoerper, LAMTOR1 antikoerper, Lamtor1 antikoerper, lamtor1.S antikoerper

Hintergrund:

Background: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

Aliases: C11orf59 antibody, LAMTOR1 antibody, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 antibody, Lipid raft adaptor protein p18 antibody, LTOR1_HUMAN antibody, p18 antibody, p27Kip1-releasing factor from RhoA antibody, p27RF-Rho antibody, PDRO antibody, PP7157 antibody, Protein associated with DRMs and endosomes antibody, Ragulator complex protein LAMTOR1 antibody, ragulator complex protein PDRO antibody, Ragulator1 antibody, RhoA activator C11orf59 antibody

UniProt: Q6IAA8