ALK Antikörper

Produktnummer ABIN7339896

Produktdetails anti-ALK Antikörper

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALK Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of Human ALK

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA:1:1000-1:5000, IHC:1:25-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ALK

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Andere Bezeichnung: ALK (ALK Produkte)

Synonyme: Tcrz antikoerper, CD246 antikoerper, NBLST3 antikoerper, ALK antikoerper, anaplastic lymphoma kinase antikoerper, anaplastic lymphoma receptor tyrosine kinase antikoerper, ALK receptor tyrosine kinase antikoerper, Alk antikoerper, ALK antikoerper

Hintergrund:

Background: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

Aliases: Alk antibody, ALK tyrosine kinase receptor antibody, ALK/EML4 fusion gene, included antibody, ALK/NPM1 fusion gene, included antibody, ALK_HUMAN antibody, anaplastic lymphoma kinase (Ki-1) antibody, Anaplastic lymphoma kinase antibody, Anaplastic lymphoma kinase Ki1 antibody, anaplastic lymphoma receptor tyrosine kinase antibody, CD 246 antibody, CD246 antibody, CD246 antigen antibody, EC 2.7.10.1 antibody, Ki 1 antibody, Ki1 antibody, mutant anaplastic lymphoma kinase antibody, NBLST 3 antibody, NBLST3 antibody, Tcrz antibody, TFG/ALK antibody

UniProt: Q9UM73

Pathways: RTK Signalweg