ALK Antikörper (AA 1402-1604)

Produktnummer ABIN7368872

Produktdetails anti-ALK Antikörper

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Bindungsspezifität: AA 1402-1604

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALK Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human ALK tyrosine kinase receptor protein (1402-1604AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ALK

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Andere Bezeichnung: ALK (ALK Produkte)

Synonyme: Tcrz antikoerper, CD246 antikoerper, NBLST3 antikoerper, ALK antikoerper, anaplastic lymphoma kinase antikoerper, anaplastic lymphoma receptor tyrosine kinase antikoerper, ALK receptor tyrosine kinase antikoerper, Alk antikoerper, ALK antikoerper

Hintergrund:

Background: Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Aliases: Alk antibody, ALK tyrosine kinase receptor antibody, ALK/EML4 fusion gene, included antibody, ALK/NPM1 fusion gene, included antibody, ALK_HUMAN antibody, anaplastic lymphoma kinase (Ki-1) antibody, Anaplastic lymphoma kinase antibody, Anaplastic lymphoma kinase Ki1 antibody, anaplastic lymphoma receptor tyrosine kinase antibody, CD 246 antibody, CD246 antibody, CD246 antigen antibody, EC 2.7.10.1 antibody, Ki 1 antibody, Ki1 antibody, mutant anaplastic lymphoma kinase antibody, NBLST 3 antibody, NBLST3 antibody, Tcrz antibody, TFG/ALK antibody

UniProt: Q9UM73

Pathways: RTK Signalweg