ABCB4 Antikörper (AA 530-693)

Produktnummer ABIN7163123

Produktdetails anti-ABCB4 Antikörper

Target: ABCB4 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4))

Bindungsspezifität: AA 530-693

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABCB4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Phosphatidylcholine translocator ABCB4 protein (530-693AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ABCB4

Target: ABCB4 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4))

Andere Bezeichnung: ABCB4 (ABCB4 Produkte)

Synonyme: ABC21 antikoerper, GBD1 antikoerper, ICP3 antikoerper, MDR2 antikoerper, MDR2/3 antikoerper, MDR3 antikoerper, PFIC-3 antikoerper, PGY3 antikoerper, zgc:172149 antikoerper, Mdr2 antikoerper, Pgy-2 antikoerper, Pgy2 antikoerper, mdr-2 antikoerper, Pgy3 antikoerper, ABCB4a antikoerper, DEFB1 antikoerper, PGP2 antikoerper, PGY2 antikoerper, PGP3 antikoerper, ABCB4 antikoerper, RUNDC3B antikoerper, ATP binding cassette subfamily B member 4 antikoerper, ATP-binding cassette, sub-family B (MDR/TAP), member 4 antikoerper, beta-defensin 1-like antikoerper, ATP-binding cassette, sub-family B (MDR/TAP), member 1B antikoerper, RUN domain-containing protein 3B antikoerper, ABCB4 antikoerper, abcb4 antikoerper, Abcb4 antikoerper, LOC100861170 antikoerper, Abcb1b antikoerper, LOC101122517 antikoerper

Hintergrund:

Background: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity).

Aliases: ABC 21 antibody, ABC B4 antibody, ABC21 antibody, ABCB 4 antibody, Abcb4 antibody, ABCB4 protein antibody, ATP binding cassette sub family B MDR/TAP member 4 antibody, ATP binding cassette sub family B member 4 antibody, ATP-binding cassette sub-family B member 4 antibody, GBD1 antibody, ICP3 antibody, MDR 3 antibody, MDR2 antibody, MDR2/3 antibody, MDR3 antibody, MDR3 P glycoprotein antibody, MDR3 P gp antibody, MDR3_HUMAN antibody, Multidrug resistance protein 3 antibody, Multiple drug resistance 3 antibody, P glycoprotein 3 antibody, P-glycoprotein 3 antibody, PFIC 3 antibody, PFIC3 antibody, PGY 3 antibody, PGY3 antibody

UniProt: P21439

Pathways: Regulation of Lipid Metabolism by PPARalpha