KLRK1 Antikörper (AA 73-216)

Produktnummer ABIN7161645

Produktdetails anti-KLRK1 Antikörper

Target: KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

Bindungsspezifität: AA 73-216

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLRK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human NKG2-D type II integral membrane protein (73-216AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KLRK1

Target: KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

Andere Bezeichnung: KLRK1 (KLRK1 Produkte)

Synonyme: KLRK1 antikoerper, NKG2D antikoerper, CD314 antikoerper, D12S2489E antikoerper, KLR antikoerper, NKG2-D antikoerper, D6H12S2489E antikoerper, Nkg2d antikoerper, Nkrp2 antikoerper, killer cell lectin like receptor K1 antikoerper, killer cell lectin-like receptor subfamily K, member 1 antikoerper, NKG2D protein antikoerper, KLRK1 antikoerper, Klrk1 antikoerper, NKG2D antikoerper

Hintergrund:

Background: Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.

Aliases: CD314 antibody, CD314 antigen antibody, D12S2489E antibody, Killer cell lectin like receptor subfamily K member 1 antibody, Killer cell lectin-like receptor subfamily K member 1 antibody, KLR antibody, KLRC4 KLRK1 readthrough antibody, KLRK1 antibody, NK cell receptor D antibody, NK lectin-like receptor antibody, NKG2 D activating NK receptor antibody, NKG2 D type II integral membrane protein antibody, NKG2-D antibody, NKG2-D type II integral membrane protein antibody, NKG2-D-activating NK receptor antibody, Nkg2d antibody, NKG2D_HUMAN antibody, NKLLR antibody, NKR P2 antibody, Nkrp2 antibody

UniProt: P26718

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process