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KLRK1 Antikörper

KLRK1 Reaktivität: Human FACS, IP, IHC (fro), Func Wirt: Maus Monoclonal 1D11 unconjugated
Produktnummer ABIN1027685
  • Target Alle KLRK1 Antikörper anzeigen
    KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
    Reaktivität
    • 57
    • 37
    • 8
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 54
    • 20
    • 5
    • 5
    • 2
    • 1
    Maus
    Klonalität
    • 53
    • 32
    • 2
    Monoklonal
    Konjugat
    • 34
    • 10
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KLRK1 Antikörper ist unkonjugiert
    Applikation
    • 51
    • 46
    • 16
    • 15
    • 15
    • 14
    • 13
    • 10
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
    Spezifität
    The mouse monoclonal antibody 1D11 recognizes an extracellular epitope of CD314 / NKG2D, a 42 kDa C-type lectin-like activating receptor expressed by NK cells, gamma/delta T cells, and CD8+ T cells.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    NKL cell line
    Klon
    1D11
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product KLRK1 Primärantikörper
  • Applikationshinweise
    Functional application: Blocking of ligand binding.
    Immunohistochemistry: Recommended dilution: 5-10 μg/mL.
    Flow cytometry: Recommended dilution: 1-4 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4
    Konservierungsmittel
    Azide free
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Valencia, Hernández-López, Martínez, Hidalgo, Zapata, Vicente, Varas, Sacedón: "Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors." in: Journal of leukocyte biology, Vol. 87, Issue 3, pp. 405-14, (2010) (PubMed).

    Hasenkamp, Borgerding, Uhrberg, Falk, Chapuy, Wulf, Jung, Trümper, Glass: "Self-tolerance of human natural killer cells lacking self-HLA-specific inhibitory receptors." in: Scandinavian journal of immunology, Vol. 67, Issue 3, pp. 218-29, (2008) (PubMed).

    Sangiolo, Martinuzzi, Todorovic, Vitaggio, Vallario, Jordaney, Carnevale-Schianca, Capaldi, Geuna, Casorzo, Nash, Aglietta, Cignetti: "Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers." in: International immunology, Vol. 20, Issue 7, pp. 841-8, (2008) (PubMed).

    Ebert, Meuter, Moser: "Homing and function of human skin gammadelta T cells and NK cells: relevance for tumor surveillance." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 7, pp. 4331-6, (2006) (PubMed).

    Wu, Groh, Spies: "T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 3, pp. 1236-40, (2002) (PubMed).

    Wu, Cherwinski, Spies, Phillips, Lanier: "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells." in: The Journal of experimental medicine, Vol. 192, Issue 7, pp. 1059-68, (2000) (PubMed).

    Bauer, Groh, Wu, Steinle, Phillips, Lanier, Spies: "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA." in: Science (New York, N.Y.), Vol. 285, Issue 5428, pp. 727-9, (1999) (PubMed).

  • Target
    KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
    Andere Bezeichnung
    CD314 (KLRK1 Produkte)
    Synonyme
    KLRK1 antikoerper, NKG2D antikoerper, CD314 antikoerper, D12S2489E antikoerper, KLR antikoerper, NKG2-D antikoerper, D6H12S2489E antikoerper, Nkg2d antikoerper, Nkrp2 antikoerper, killer cell lectin like receptor K1 antikoerper, killer cell lectin-like receptor subfamily K, member 1 antikoerper, NKG2D protein antikoerper, KLRK1 antikoerper, Klrk1 antikoerper, NKG2D antikoerper
    Hintergrund
    Killer cell lectin like receptor K1,CD314, also known as NKG2D (natural killer receptor G2D) or KLRK1 (killer cell lectin-like receptor subfamily K, member 1), is a homodimeric C-type lectin-like activating receptor and costimulator with type II membrane orientation (C teminus extracellular). CD314 homodimers are associated with DAP10, a membrane adaptor protein that signals similar to CD28 by recruitment of phosphatidylinositol 3-kinase. Engagement of CD314 amplifies antigen-specific T cell responses in CD314-positive T cell populations. In NK cells, CD314 is a primary activating receptor. As CD314 ligands the MHC class-I chain-related proteins A and B (MICA, MICB) and UL16-binding proteins (ULBPs) have been identified.,NKG2D, KLRK1, KLR
    Gen-ID
    22914
    UniProt
    P26718
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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