MLL5/KMT2E Antikörper (AA 182-316) (FITC)

Produktnummer ABIN7155468

Produktdetails anti-MLL5/KMT2E Antikörper (FITC)

Target: MLL5/KMT2E (MLL5) (Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog) (MLL5))

Bindungsspezifität: AA 182-316

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLL5/KMT2E Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Histone-lysine N-methyltransferase 2E protein (182-316AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MLL5/KMT2E

Target: MLL5/KMT2E (MLL5) (Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog) (MLL5))

Andere Bezeichnung: KMT2E (MLL5 Produkte)

Synonyme: HDCMC04P antikoerper, MLL5 antikoerper, 1810033J14Rik antikoerper, 9530077A04Rik antikoerper, D230038D11Rik antikoerper, Mll5 antikoerper, lysine methyltransferase 2E antikoerper, lysine (K)-specific methyltransferase 2E antikoerper, KMT2E antikoerper, Kmt2e antikoerper

Hintergrund:

Background: Histone methyltransferase that specifically mono- and dimethylates \'Lys-4\' of histone H3 (H3K4me1 and H3K4me2). H3 \'Lys-4\' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.

Aliases: HDCMC04P antibody, Histone lysine N methyltransferase MLL5 antibody, Histone-lysine N-methyltransferase MLL5 antibody, KMT2E antibody, Lysine N methyltransferase 2E antibody, Lysine N-methyltransferase 2E antibody, MGC70452 antibody, Mll5 antibody, MLL5_HUMAN antibody, Myeloid/lymphoid or mixed lineage leukemia 5 (trithorax homolog, Drosophila) antibody, Myeloid/lymphoid or mixed lineage leukemia 5 antibody, Myeloid/lymphoid or mixed lineage leukemia protein 5 antibody, Myeloid/lymphoid or mixed-lineage leukemia protein 5 antibody

UniProt: Q8IZD2

Pathways: Retinoic Acid Receptor Signaling Pathway, Warburg Effekt