MCC Antikörper (AA 479-611) (HRP)

Produktnummer ABIN7148297

Produktdetails anti-MCC Antikörper (HRP)

Target: MCC (Mutated in Colorectal Cancers (MCC))

Bindungsspezifität: AA 479-611

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCC Antikörper ist konjugiert mit HRP

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Colorectal mutant cancer protein (479-611AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MCC

Target: MCC (Mutated in Colorectal Cancers (MCC))

Andere Bezeichnung: MCC (MCC Produkte)

Synonyme: MCC antikoerper, mcc1 antikoerper, MCC1 antikoerper, D18Ertd451e antikoerper, E330037C19 antikoerper, RGD1561988 antikoerper, mutated in colorectal cancers antikoerper, MCC antikoerper, mcc antikoerper, Mcc antikoerper

Hintergrund:

Background: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).

Aliases: Colorectal mutant cancer protein antibody, CRCM_HUMAN antibody, DKFZp762O1615 antibody, FLJ38893 antibody, FLJ46755 antibody, MCC 1 antibody, MCC antibody, MCC1 antibody, Mutated in colorectal cancers antibody, Protein MCC antibody

UniProt: P23508