MCC Antikörper (AA 479-611)
-
- Target Alle MCC Antikörper anzeigen
- MCC (Mutated in Colorectal Cancers (MCC))
-
Bindungsspezifität
- AA 479-611
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser MCC Antikörper ist unkonjugiert
-
Applikation
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human Colorectal mutant cancer protein (479-611AA)
- Isotyp
- IgG
- Top Product
- Discover our top product MCC Primärantikörper
-
-
- Applikationshinweise
- Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- MCC (Mutated in Colorectal Cancers (MCC))
- Andere Bezeichnung
- MCC (MCC Produkte)
- Synonyme
- MCC antikoerper, mcc1 antikoerper, MCC1 antikoerper, D18Ertd451e antikoerper, E330037C19 antikoerper, RGD1561988 antikoerper, mutated in colorectal cancers antikoerper, MCC antikoerper, mcc antikoerper, Mcc antikoerper
- Hintergrund
-
Background: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).
Aliases: Colorectal mutant cancer protein antibody, CRCM_HUMAN antibody, DKFZp762O1615 antibody, FLJ38893 antibody, FLJ46755 antibody, MCC 1 antibody, MCC antibody, MCC1 antibody, Mutated in colorectal cancers antibody, Protein MCC antibody
- UniProt
- P23508
-