Casein Kinase 1 delta Antikörper (Isoform delta)

Produktnummer ABIN7146858

Produktdetails anti-Casein Kinase 1 delta Antikörper

Target: Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))

Bindungsspezifität: AA 152-398, Isoform delta

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Casein Kinase 1 delta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Casein kinase I isoform delta protein (152-398AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:1000-1:2000, IF:1:200-1:500, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Casein Kinase 1 delta

Target: Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))

Andere Bezeichnung: CSNK1D (CSNK1D Produkte)

Synonyme: ASPS antikoerper, CKIdelta antikoerper, FASPS2 antikoerper, HCKID antikoerper, 1200006A05Rik antikoerper, AA409348 antikoerper, D930010H05Rik antikoerper, CKI-delta antikoerper, CKId antikoerper, csnk1d antikoerper, wu:fb69b03 antikoerper, wu:fj97a05 antikoerper, zgc:77627 antikoerper, CSNK1D antikoerper, ckIdelta antikoerper, Csnk1d antikoerper, csnk1dl antikoerper, wu:fb50c04 antikoerper, zgc:63971 antikoerper, casein kinase 1 delta antikoerper, casein kinase 1, delta antikoerper, casein kinase 1, delta b antikoerper, casein kinase 1 delta S homeolog antikoerper, casein kinase 1, delta a antikoerper, CSNK1D antikoerper, Csnk1d antikoerper, csnk1d antikoerper, csnk1db antikoerper, Bm1_37175 antikoerper, csnk1d.S antikoerper, csnk1da antikoerper

Hintergrund:

Background: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Aliases: Casein Kinase 1 delta antibody, Casein kinase I delta isoform antibody, Casein kinase I isoform delta antibody, CKI delta antibody, CKI-delta antibody, CKId antibody, CKIdelta antibody, CSNK 1D antibody, CSNK1D antibody, HCKID antibody, KC1D_HUMAN antibody, Protein kinase CK1 delta antibody

UniProt: P48730

Pathways: Hedgehog Signalweg, M Phase