Rekombinanter PTEN Antikörper (pSer380)

Produktnummer ABIN7321442

Produktdetails anti-PTEN Antikörper

Target: PTEN (Phosphatase and Tensin Homolog (PTEN))

Antikörpertyp: Recombinant Antibody

Bindungsspezifität: pSer380

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PTEN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Phospho-PTEN (S380)

Klon: 4D10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PTEN

Target: PTEN (Phosphatase and Tensin Homolog (PTEN))

Andere Bezeichnung: PTEN (PTEN Produkte)

Synonyme: 10q23del antikoerper, BZS antikoerper, CWS1 antikoerper, DEC antikoerper, GLM2 antikoerper, MHAM antikoerper, MMAC1 antikoerper, PTEN1 antikoerper, TEP1 antikoerper, 2310035O07Rik antikoerper, A130070J02Rik antikoerper, AI463227 antikoerper, B430203M17Rik antikoerper, Mmac antikoerper, PTENP1 antikoerper, wu:fc52g04 antikoerper, zgc:73086 antikoerper, fa11a08 antikoerper, fb73f10 antikoerper, fc83f12 antikoerper, fd16b10 antikoerper, fk90e11 antikoerper, pten antikoerper, si:bz1g13.4 antikoerper, wu:fa11a08 antikoerper, wu:fb73f10 antikoerper, wu:fc83f12 antikoerper, wu:fd16b10 antikoerper, wu:fk90e11 antikoerper, phosphatase and tensin homolog antikoerper, phosphatase and tensin homolog L homeolog antikoerper, phosphatase and tensin homolog A antikoerper, phosphatase and tensin homolog B antikoerper, PTEN antikoerper, Pten antikoerper, pten.L antikoerper, ptena antikoerper, ptenb antikoerper

Hintergrund:

Background: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.

Aliases: Phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1

UniProt: P60484

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagie, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling