KCNAB1 Antikörper

Produktnummer ABIN7117721

Produktdetails anti-KCNAB1 Antikörper

Target: KCNAB1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 1 (KCNAB1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNAB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: potassium voltage-gated channel, shaker-related subfamily, beta member 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu KCNAB1

Target: KCNAB1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 1 (KCNAB1))

Andere Bezeichnung: KCNAB1 (KCNAB1 Produkte)

Synonyme: KCNAB1 antikoerper, zgc:113627 antikoerper, AKR6A3 antikoerper, KCNA1B antikoerper, KV-BETA-1 antikoerper, Kvb1.3 antikoerper, hKvBeta3 antikoerper, hKvb3 antikoerper, Kvbeta1.1 antikoerper, KVBETA1 antikoerper, Kv-beta-1 antikoerper, Akr8a8 antikoerper, mKv(beta)1 antikoerper, KvBeta3 antikoerper, potassium voltage-gated channel subfamily A member regulatory beta subunit 1 antikoerper, potassium voltage-gated channel, shaker-related subfamily, beta member 1 a antikoerper, potassium voltage-gated channel, shaker-related subfamily, beta member 1 antikoerper, KCNAB1 antikoerper, kcnab1a antikoerper, Kcnab1 antikoerper

Hintergrund: Synonyms:KCNA1B Background:Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits(PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits(By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity(By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members(PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels(PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure(PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4(PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6(By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1(PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity(By similarity). Binds NADPH, this is required for efficient down-regulation of potassium channel activity(PubMed:17540341). Has NADPH-dependent aldoketoreductase activity(By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity(By similarity).

Molekulargewicht: 68 kDa

Gen-ID: 7881

UniProt: Q14722