KCNAB1 Antikörper (AA 287-401)

Produktnummer ABIN7175618

Produktdetails anti-KCNAB1 Antikörper

Target: KCNAB1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 1 (KCNAB1))

Bindungsspezifität: AA 287-401

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNAB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Voltage-gated potassium channel subunit beta-1 protein (287-401AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KCNAB1

Target: KCNAB1 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 1 (KCNAB1))

Andere Bezeichnung: KCNAB1 (KCNAB1 Produkte)

Synonyme: KCNAB1 antikoerper, zgc:113627 antikoerper, AKR6A3 antikoerper, KCNA1B antikoerper, KV-BETA-1 antikoerper, Kvb1.3 antikoerper, hKvBeta3 antikoerper, hKvb3 antikoerper, Kvbeta1.1 antikoerper, KVBETA1 antikoerper, Kv-beta-1 antikoerper, Akr8a8 antikoerper, mKv(beta)1 antikoerper, KvBeta3 antikoerper, potassium voltage-gated channel subfamily A member regulatory beta subunit 1 antikoerper, potassium voltage-gated channel, shaker-related subfamily, beta member 1 a antikoerper, potassium voltage-gated channel, shaker-related subfamily, beta member 1 antikoerper, KCNAB1 antikoerper, kcnab1a antikoerper, Kcnab1 antikoerper

Hintergrund:

Background: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH, this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).

Aliases: hKvb3 antibody, hKvBeta3 antibody, K(+) channel subunit beta-1 antibody, KCAB1_HUMAN antibody, KCNA1B antibody, KCNAB1 antibody, Kv-beta-1 antibody, Kvb1.3 antibody, Voltage-gated potassium channel beta-1 subunit antibody, Voltage-gated potassium channel subunit beta-1 antibody

UniProt: Q14722