AG2 antikoerper, GOB-4 antikoerper, HAG-2 antikoerper, PDIA17 antikoerper, XAG-2 antikoerper, Agr2h antikoerper, Gob-4 antikoerper, mAG-2 antikoerper, wu:fj29g05 antikoerper, zgc:112187 antikoerper, agr2 antikoerper, hag3 antikoerper, hag-3 antikoerper, bcmp11 antikoerper, MGC89004 antikoerper, XAgr2 antikoerper, agr2-A antikoerper, anterior gradient 2, protein disulphide isomerase family member antikoerper, anterior gradient 2 antikoerper, anterior gradient 3, protein disulphide isomerase family member antikoerper, anterior gradient 2, protein disulphide isomerase family member S homeolog antikoerper, AGR2 antikoerper, Agr2 antikoerper, agr2 antikoerper, agr3 antikoerper, agr2.S antikoerper
Hintergrund
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.